SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population
SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population
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DOI：
10.1002/ajmg.b.32007
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发表时间：
2012-01-01
影响因子：
2.8
通讯作者：
Macaya, Alfons
中科院分区：
文献类型：
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作者：
Carreno, Oriel;Corominas, Roser;Macaya, Alfons
非选择性阳离子通道的瞬时受体电位（TRP）超家族参与与偏头痛病理生理学可能相关的几个过程，包括多模式感觉和疼痛感知、中枢和外周敏化以及钙稳态的调节。为了确定TRP基因中可能增加偏头痛遗传易感性的单核苷酸多态性（SNPs），我们进行了一项病例对照遗传关联研究，包括1,040例病例和1,037例对照。我们对149个SNPs进行了基因分型，涵盖了已知脑表达的14个TRP基因。该两阶段研究包括555和485名西班牙白人患者的样本，根据ICHD-II诊断无先兆偏头痛（MO）或有先兆偏头痛（MA）的标准进行选择。在发现样本中，10个TRP基因中的19个SNP显示名义关联（P
The transient receptor potential (TRP) superfamily of non-selective cationic channels are involved in several processes plausibly relevant to migraine pathophysiology, including multimodal sensory and pain perception, central and peripheral sensitization, and regulation of calcium homeostasis. With the aim of identifying single nucleotide polymorphisms (SNPs) in TRP genes that may confer increased genetic susceptibility to migraine, we carried out a casecontrol genetic association study with replication, including a total of 1,040 cases and 1,037 controls. We genotyped 149 SNPs covering 14 TRP genes with known brain expression. The two-stage study comprised samples of 555 and 485 Spanish, Caucasian patients, selected according to the ICHD-II criteria for the diagnosis of migraine without aura (MO) or migraine with aura (MA). In the discovery sample, 19 SNPs in ten TRP genes showed nominal association (P