Imaging of enthesitis by an LED-based photoacoustic system.
Imaging of enthesitis by an LED-based photoacoustic system.
复制标题
通过基于LED的光声系统对肠炎的成像。
DOI：
10.1117/1.jbo.25.12.126005
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发表时间：
2020-12
影响因子：
3.5
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Jo J;Xu G;Schiopu E;Chamberland D;Gandikota G;Wang X
重要性：血清阴性脊柱关节病（SpA）的一个关键病理特征是肌腱和韧带插入骨处的炎症（附着点炎）。目的：我们探讨了新兴的光声（PA）成像在诊断SpA中的潜力，并回顾了其在检测SpA相关跟腱附着点炎中的可行性。方法：采用基于发光二极管（LED）的PA和超声联合系统。在850 nm波长下采集PA图像，沿着每个跟腱附着区的长轴和短轴，该波长在描绘增加的血容量（即，充血）。为了评估指示附着点炎症的充血，在成像的肌腱中量化两个参数，包括伪彩色PA图像中彩色像素的平均强度和密度。10名SpA患者均符合SpA国际协会（ASAS）SpA评估标准，并根据委员会认证的风湿病学家通过临床检查发现有跟腱附着点炎，这些患者均被纳入本研究。结果如下：将这10名SpA患者的跟腱附着点炎的PA和多普勒超声成像与10名健康志愿者的PA和多普勒超声成像进行比较，在应用测试中产生统计学显著差异（）。结论：这项初步的临床研究表明，基于LED的PA成像有望在风湿病门诊环境中对SpA附着点炎进行敏感和客观的评估。
Significance: One key pathological characteristic of seronegative spondyloarthropathy (SpA) is inflammation at the insertion of tendons and ligaments into the bone (enthesitis). Aim: We explore the potential of the emerging photoacoustic (PA) imaging in diagnosis of SpA and review its feasibility in detecting SpA-associated Achilles tendon enthesitis. Approach: A light-emitting diode (LED)-based PA and ultrasound combined system was employed. The PA images, both along the long and the short axes of each Achilles tendon insertion region, were acquired at 850-nm wavelength, which is sensitive in depicting increased blood volume (i.e., hyperemia). To assess the hyperemia indicating enthesis inflammation, two parameters were quantified in the imaged tendons, including the average intensity and the density of the color pixels in the pseudo-color PA images. Ten SpA patients, all of which met Assessment of SpA International Society (ASAS) criteria for SpA and were found to have Achilles enthesitis by clinical exam according to a board-certified rheumatologist, were included in the study. Results: The PA and Doppler ultrasound imaging of Achilles enthesitis resulting from these 10 SpA patients were compared to those from 10 healthy volunteers, leading to statistically significant differences () in the applied -tests. Conclusions: This preliminary clinical study suggests that the LED-based PA imaging holds a promise for sensitive and objective assessment of SpA enthesitis in an outpatient setting of the rheumatology clinic.