HIGH-FIBER DIETS AND REDUCED RISK OF BREAST-CANCER
HIGH-FIBER DIETS AND REDUCED RISK OF BREAST-CANCER
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DOI：
10.1002/ijc.2910560204
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发表时间：
1994-01-15
影响因子：
6.4
通讯作者：
ROHAN, TE
中科院分区：
文献类型：
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作者：
BAGHURST, PA;ROHAN, TE
在一项病例对照研究中，对来自澳大利亚大都市阿德莱德的451名乳腺癌妇女和451名基于人群的对照进行了研究，研究了乳腺癌的风险与膳食纤维和各种纤维成分的摄入量的关系。通过自我管理的定量食物频率问卷来估计摄入量，并相对于纤维密度最低的五分位数中女性的任意分配的统一风险，估计纤维密度的每个五分位数（摄入量/总能量摄入的兆焦耳）的乳腺癌风险。有非常显着的相对风险降低与总膳食纤维的一些成分的摄入量增加。在总非淀粉多糖（NSP）估计膳食密度最高的20%的女性中，乳腺癌的相对风险为0.46，并且五分位数趋势检验在p < 0.001时具有显著性。通过Englyst分析方法定义的各种纤维组分的单独风险估计显示，与来自不溶性NSP的甘露糖和来自可溶性NSP的葡萄糖的高密度相关的风险降低最高。对于许多纤维成分，绝经前和绝经后妇女的相对风险点估计值非常相似，尽管后者（占所有病例的三分之二以上）的结果在统计学上更显着。这项研究为最近的推测提供了强有力的支持，即富含膳食纤维的食物可能有助于预防乳腺癌。(C)1994 Wiley-Liss，Inc.
In a case-control study of 451 women with breast cancer and 451 population-based controls from metropolitan Adelaide, Australia, the risk of breast cancer was studied in relation to intake of dietary fiber and various fiber components. Intakes were estimated by means of a self-administered quantitative food-frequency questionnaire, and risks of breast cancer were estimated for each quintile of fiber density (intake/megajoule of total energy intake) relative to an arbitrarily assigned risk of unity for women in the lowest quintile of fiber density. There were highly significant reductions in relative risk associated with increasing intake of a number of components of total dietary fiber. In women with the highest 20% estimated dietary densities of total non-starch polysaccharides (NSP), the relative risk of breast cancer was 0.46, and a test for trend across the quintiles was significant at p < 0.001. Separate risk estimations for various fiber components defined by the Englyst method of analysis revealed highest risk reductions associated with high densities of mannose from insoluble NSP and of glucose from soluble NSP. For many fiber components the point estimates of relative risk were quite similar both for pre- and for postmenopausal women, although results for the latter (who comprised over two thirds of all cases) were statistically more significant. The study provides strong support for recent conjecture that foods rich in dietary fiber may be protective against breast cancer. (C) 1994 Wiley-Liss, Inc.