Mechanisms of neural stem cell fate determination: extracellular cues and intracellular programs.
Mechanisms of neural stem cell fate determination: extracellular cues and intracellular programs.
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DOI：
10.2174/157488806776956887
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发表时间：
2006-05-01
影响因子：
2.7
通讯作者：
Nakashima, Kinichi
中科院分区：
文献类型：
--
作者：
Abematsu, Masahiko;Smith, Ian;Nakashima, Kinichi
多能神经干细胞(NSC)具有自我更新和生成三种主要的中枢神经系统(CNS)细胞类型：神经元、星形胶质细胞和少突胶质细胞的能力。然而，控制NSC命运的分子机制尚不完全清楚。最近的研究表明，细胞因子和转录因子等可溶性蛋白介质在决定细胞命运的过程中发挥着关键作用。此外，表观遗传基因调控作为细胞固有程序在细胞谱系的规范中扮演着重要的细胞内角色。在这篇综述中，我们重点介绍了NSC命运指定的机制及其在再生医学领域的可能贡献的最新进展。
Multipotent neural stem cells (NSC) possess the ability to self-renew and to generate the three major central nervous system (CNS) cell types: neurons, astrocytes and oligodendrocytes. However, the molecular mechanisms that control NSC fate specification are not yet fully understood. Recent studies have provided evidence that soluble protein mediators such as cytokines and transcriptional factors play critical roles in cell fate determination. Furthermore, it has become apparent that epigenetic gene regulation plays an important intracellular role as cell-intrinsic programs in the specification of cell lineages. In this review, we focus on recent progress that addresses the mechanisms of NSC fate specification and their possible contribution in the field of regenerative medicine.