Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame.
Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame.
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DOI：
10.1007/s10620-015-3977-1
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发表时间：
2016-05
影响因子：
3.1
通讯作者：
Gores GJ
中科院分区：
文献类型：
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作者：
Ibrahim SH;Hirsova P;Malhi H;Gores GJ
随着肥胖的流行，非酒精性脂肪性肝病（NAFLD）已成为一个日益流行的公共卫生问题。疾病进展的机制尚不清楚，缺乏有效的治疗方法。因此，有必要了解负责疾病发展和进展的致病机制，以开发创新疗法。为了实现这一目标，概括人类疾病的实验动物模型是必要的，特别是因为在人类身上进行NAFLD的致病机制研究更加困难或不道德。为了模拟人类NAFLD和非酒精性脂肪性肝炎（NASH），在小鼠身上进行了大量关于NASH病理生理和治疗的研究。本文综述了近年来已知的基于饮食、遗传和炎症的NASH动物模型，重点介绍了该领域的主要进展。
With the obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has become a public health problem with increasing prevalence. The mechanism of disease progression remains obscure and effective therapy is lacking. Therefore, there is a need to understand the pathogenic mechanisms responsible for disease development and progression in order to develop innovative therapies. To accomplish this goal, experimental animal models that recapitulate the human disease are necessary, especially, since causative mechanistic studies of NAFLD are more difficult or unethical to perform in humans. A large number of studies regarding the pathophysiology and treatment of NASH have been undertaken in mice to model human NAFLD and nonalcoholic steatohepatitis (NASH). This review discusses the known dietary, genetic and inflammation based animal models of NASH described in recent years, with a focus on the major advances made in this field.