EFFECT OF ZOLPIDEM ON SLEEP IN INSOMNIAC PATIENTS
EFFECT OF ZOLPIDEM ON SLEEP IN INSOMNIAC PATIENTS
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DOI：
10.1007/bf00558070
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发表时间：
1989-01-01
影响因子：
2.9
通讯作者：
MONTI, JM
中科院分区：
文献类型：
--
作者：
MONTI, JM
唑吡坦10 mg口服的疗效观察通过多导睡眠图记录评估持续性心理生理性失眠症患者的睡眠状况。在两周的治疗过程中，观察到睡眠有改善，无反跳性失眠。睡眠开始后的清醒时间在一周后减少，两周后增加，而睡眠潜伏期保持减少。唑吡坦显著延长了第二阶段睡眠的持续时间，但不影响慢波睡眠或快速眼动睡眠。对睡眠改善的主观评估与睡眠实验室的结果有很好的相关性。唑吡坦在给药后的第二天早上并没有损害患者的即时记忆或精神运动能力。用药期间的不良反应包括嗜睡、乏力、头痛、焦虑和易怒。它们是温和或中度的，醒来后很快就消失了。
The effect of zolpidem 10 mg p.o. on sleep in patients with persistent psychophysiological insomnia was assessed by polysomnographic recordings. An improvement in sleep with no rebound insomnia was observed during treatment for two weeks. Time awake after the onset of sleep was reduced after one week and increased after two weeks, whereas sleep latency remained reduced. Zolpidem markedly increased the duration of Stage 2 sleep without affecting either slow wave sleep or REM sleep. Subjective evaluation of improvement in sleep was well correlated with sleep laboratory findings. Zolpidem did not impair the immediate memory or psychomotor performance of patients on the morning after its administration. Side-effects during the period of drug administration included drowsiness, fatigue, headache, anxiety and irritability. They were mild or moderate and wore off soon after awakening.