Remission in rheumatoid arthritis: agreement of the disease activity score (DAS28) with the ARA preliminary remission criteria
Remission in rheumatoid arthritis: agreement of the disease activity score (DAS28) with the ARA preliminary remission criteria
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DOI：
10.1093/rheumatology/keh297
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发表时间：
2004-10-01
期刊：
影响因子：
5.5
通讯作者：
Van Riel, PLCM
中科院分区：
文献类型：
--
作者：
Fransen, J;Creemers, MCW;Van Riel, PLCM
目标。确定RA疾病活动评分(DAS28)中的哪个分界点对应于达到ARA的临床缓解标准。奈梅亨RA初始队列中的患者的疾病活动性每3个月进行一次系统评估。对于所有的访问，修改了ARA的临床缓解初步标准，并计算了DAS28。采用受试者工作特性分析，确定符合ARA标准的DAS28诊断标准的敏感度和特异度最高。378名患者提供了4,378次访问。在6.5%的来访中，五个项目中的四个项目和1.5%的修订后的ARA标准的所有五个项目都得到了满足。符合ARA标准的DAS28的最佳分界点被确定为2.66。DAS28
Objective. To determine which cut-off point in the RA disease activity score (DAS28) corresponds to fulfilment of the ARA criteria for clinical remission.Methods. The disease activity of patients included in the Nijmegen RA inception cohort was systematically assessed every 3 months. For all visits, a modification of the ARA preliminary criteria for clinical remission was applied and the DAS28 was calculated. Receiver operating characteristic analysis was used to determine the cut-off point with maximum sensitivity and specificity in DAS28 corresponding with fulfilment of the modified ARA criteria.Results. Three hundred and seventy-eight patients contributed 4378 visits. In 6.5% of the visits four of the five items and in 1.5% all five items of the modified ARA criteria were fulfilled. The optimal cut-off point for the DAS28 that corresponds to fulfilment of the modified ARA criteria was determined to be 2.66.Conclusion. DAS28