Remotely monitored Baduanjin exercise in moderate-to-severe chronic obstructive pulmonary disease patients (BROCADE): A study protocol.
Remotely monitored Baduanjin exercise in moderate-to-severe chronic obstructive pulmonary disease patients (BROCADE): A study protocol.
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DOI：
10.1097/md.0000000000032079
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发表时间：
2022-12-30
期刊：
影响因子：
1.6
通讯作者：
中科院分区：
文献类型：
--
作者：
八段锦是一种传统的中国运动养生法，用于治疗各种慢性疾病，并与心理和身体的好处。然而，它对慢性阻塞性肺疾病（COPD）患者的益处尚不清楚。本研究旨在通过远程监测评估八段锦运动治疗中重度COPD（博卡）患者的有效性、安全性和潜在机制。本研究方案描述了一项多中心、开放标签、前瞻性随机计算机断层扫描。在筛选和知情同意过程后，共有150名符合入选标准的个体将参加本研究。所有参与者都将接受常规药物治疗和生活方式干预。他们将被随机分配到对照组、经典肺康复组或八段锦组，这些组将接受远程监控的八段锦锻炼，每天累计持续1小时，每周3次，持续12周。参与者将被跟踪24周。主要结局为6分钟步行距离和圣乔治呼吸问卷指数。次要结局为肺功能、胸大肌和皮下脂肪的横截面积、改良医学研究理事会评分、COPD评估测试问卷结果、肢体肌力和生活质量。将监测和记录可能发生的任何不良事件。这项研究正在进行中，一旦完成，将提交给同行评审期刊发表。一种新的嗜中性粒细胞相关的炎症机制将有可能被确定。此外，本研究结果将为中重度COPD患者提供一种安全、有效、简便、可操作的八段锦运动方案，旨在改善患者的预后和生活质量。
Baduanjin is a traditional Chinese exercise regimen used to treat various chronic illnesses and is associated with both psychological and physical benefits. However, its benefits for patients suffering from chronic obstructive pulmonary disease (COPD) are unclear. This study aims to assess the efficacy, safety, and underlying mechanisms of Baduanjin exercise in patients with moderate-to-severe COPD (BROCADE) by remote monitoring. This study protocol describes a multicenter, open-label, prospective randomized computed tomography. A total of 150 individuals who meet the inclusion criteria after the screening and consent processes will take part in the study. All participants will be provided routine medication and lifestyle interventions. They will be randomly assigned to a control group, a classical pulmonary rehabilitation group, or a Baduanjin group, which will undergo remotely monitored Baduanjin exercises for a cumulative duration of 1 hour per day, three times per week for 12 weeks. The participants will be followed for 24 weeks. The primary outcomes will be a 6-minutes walking distance and St. George’s Respiratory Questionnaire index. The secondary outcomes will be lung function, cross-sectional area of the pectoralis major and subcutaneous fat, modified Medical Research Council score, COPD assessment test questionnaire results, extremity muscle strength, and quality of life. Any adverse events that may occur will be monitored and recorded. This study is ongoing and will be submitted to a peer-reviewed journal for publication once completed. A novel neutrophil-related inflammatory mechanism will potentially be identified. In addition, the study results will provide a safe, effective, simple and operational Baduanjin exercise protocol for moderate-to-severe COPD patients aimed at improving prognosis and quality of life.
影响因子：
2.9
作者：
Gaveikaite V;Fischer C;Schonenberg H;Pauws S;Kitsiou S;Chouvarda I;Maglaveras N;Roca J
通讯作者：
Roca J