Cardiovascular risk factors and Alzheimer's disease.
Cardiovascular risk factors and Alzheimer's disease.
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DOI：
10.1007/s11883-004-0056-z
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发表时间：
2004-07-01
影响因子：
5.8
通讯作者：
Mayeux, Richard
中科院分区：
文献类型：
--
作者：
Luchsinger, Jose A;Mayeux, Richard
阿尔茨海默病是一种破坏性疾病，发病率正在上升。阿尔茨海默病目前还没有已知的预防或治疗方法。心血管危险因素在老年人中普遍存在并增加，关于可改变的心血管危险因素与阿尔茨海默病之间的关联，有相互矛盾的报道。这些关联的机制尚不确定，但它们可能是直接和脑血管疾病相关机制结合的结果。从这个角度来看，从实验室、临床和流行病学研究来看，糖尿病和高胰岛素血症似乎有最有力的证据。研究还表明，高血压、高脂血症、高同型半胱氨酸血症和吸烟是阿尔茨海默病的潜在重要危险因素。
Alzheimer's disease is a devastating condition that is increasing in prevalence. No known prevention or cure exists for Alzheimer's disease. Cardiovascular risk factors are prevalent and increase in the elderly, and there have been conflicting reports of associations between modifiable cardiovascular risk factors and Alzheimer's disease. The mechanisms for these associations are uncertain, but they are likely to be the result of a combination of direct and cerebrovascular disease-related mechanisms. From this standpoint, diabetes and hyperinsulinemia seem to have the strongest evidence from laboratory, clinical, and epidemiologic studies. Studies have also indicated that hypertension, hyperlipidemia, hyperhomocysteinemia, and smoking are potentially important risk factors for Alzheimer's disease.