Angiolipoma of the buccal mucosa: a possible role of mast cell-derived VEGF in its enhanced vascularity
Angiolipoma of the buccal mucosa: a possible role of mast cell-derived VEGF in its enhanced vascularity
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DOI：
10.1111/j.1600-0714.2004.00230.x
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发表时间：
2005-01-01
影响因子：
3.3
通讯作者：
Saku, T
中科院分区：
文献类型：
--
作者：
Ida-Yonemochi, H;Swelam, W;Saku, T
本文报告一例发生于69岁男性口腔粘膜的血管脂肪瘤。患者发现口腔粘膜有无痛性肿块已有2年。手术切除的肿瘤直径为9毫米，主要位于粘膜下层，灶性扩展到肌层。组织学上，肿瘤边界清楚，由成熟的脂肪细胞和纤维结缔组织增殖而成，内含许多小血管，分布均匀。血管内可见大量弥漫性的肥大细胞，尤其是血管周围的肥大细胞呈血管内皮细胞生长因子免疫阳性，提示肥大细胞产生的血管内皮生长因子在该特殊肿瘤的血管增殖中起重要作用。
A case of angiolipoma occurring in the buccal mucosa of a 69-year-old male is described. The patient had noticed a painless mass in his buccal mucosa for 2 years. The surgically removed tumor, measuring 9 mm in diameter, was mainly located in the submucosal layer with focal expansion into the muscle layer. Histologically, the tumor was well-demarcated and composed of proliferations of mature fat cells and fibrous connective tissue containing many small blood vessels, which were evenly distributed. There was diffuse infiltration of a large number of mast cells, which were immunopositive for vascular endothelial growth factor (VEGF) especially around blood vessels, suggesting that VEGF produced by mast cells in angiolipomas plays an important role in the vascular proliferation in this particular tumor.