Comparative in vitro study on binary Mg-RE (Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu) alloy systems
Comparative in vitro study on binary Mg-RE (Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu) alloy systems
复制标题
二元 Mg-RE（Sc、Y、La、Ce、Pr、Nd、Sm、Eu、Gd、Tb、Dy、Ho、Er、Tm、Yb 和 Lu）合金体系的体外比较研究
DOI：
10.1016/j.actbio.2019.11.013
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发表时间：
2020-01-15
影响因子：
9.7
通讯作者：
Guan, Shaokang
中科院分区：
文献类型：
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作者：
Liu, Jianing;Bian, Dong;Guan, Shaokang
正确选择合金元素是开发具有优良上级力学性能和生物性能的新型可生物降解镁合金的关键。与有关营养元素（Ca、Zn、Sr等）的各种报道相比，作为生物医用镁合金的合金元素，关于如何选择合适的稀土元素（REE）作为镁合金元素的信息有限。本工作在Mg中分别添加Sc、Y、La、Ce、Pr、Nd、Sm、Eu、Gd、Tb、Du、Ho、Er、Tm、Yb和Lu等16种稀土元素，制备了不同组成点的二元Mg-RE模型合金。在相同的工作历史条件下，进行了对比研究，考察了各种稀土元素对镁合金显微组织、力学性能、腐蚀行为和生物相容性的影响。对16种稀土元素的影响程度进行了排序。结果表明，部分Mg-RE合金中存在第二相，其主要成分为Mg 12 RE。通过在Mg中添加不同含量的稀土元素，可以在较大范围内调节Mg-RE二元合金的力学性能。镁-轻稀土合金的耐蚀性普遍优于镁-重稀土合金。在生物相容性方面，Mg-RE模型合金对MC 3 T3-E1细胞无细胞毒性作用。除Mg-Lu合金模型外，其余实验用Mg-RE模型合金的溶血率均低于5%。总之，不同稀土元素的加入可以从不同方面改善镁合金的性能。本文的研究工作对稀土作为镁合金化元素的研究有了更深入的认识，并提出了未来生物医用镁稀土合金的研究方向。作为生物医用镁合金的合金元素，到目前为止，关于如何选择合适的稀土元素（REE）作为镁合金元素的信息有限。本文通过在Mg中分别添加Sc、Y、La、Ce、Pr、Nd、Sm、Eu、Gd、Tb、Du、Ho、Er、Tm、Yb和Lu等16种稀土元素制备不同成分点的二元Mg-RE模型合金，研究了各种稀土元素对Mg-RE模型合金显微组织、力学性能、研究了镁在相同工作历史条件下的腐蚀行为和生物相容性，并对16种稀土元素的影响程度进行了排序。本文的工作为稀土镁合金的研究提供了新的思路，并提出了未来稀土镁合金的研究方向。(C)2019 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
Correct selection of alloying elements is important for developing novel biodegradable magnesium alloys with superior mechanical and biological performances. In contrast to various reports on nutrient elements (Ca, Zn, Sr, etc.) as alloying elements of biomedical magnesium alloys, there is limited information about how to choose the right rare earth elements (REEs) as alloying elements of magnesium. In this work, 16 kinds of REEs were individually added into Mg, including Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Du, Ho, Er, Tm, Yb and Lu, to fabricate binary Mg-RE model alloys with different composition points. Under the same working history, comparative studies were undertaken and the impact of each kind of rare earth element on the microstructure, mechanical property, corrosion behavior and biocompatibility of Mg were investigated. The corresponding influence level for the 16 kinds of REEs were ranked. The results showed that the second phases were detected in some Mg-RE alloys, which were mainly composed of Mg12RE. By adding different REEs into Mg with proper contents, the mechanical properties of resulting Mg-RE binary alloys could be adjusted in wide range. The corrosion resistance of Mg-light REE alloys was generally better than Mg-heavy REE alloys. As for biocompatibility, Mg-RE model alloys showed no cytotoxic effect on MC3T3-E1 cells. The hemolysis rates of all experimental Mg-RE model alloys were lower than 5% except for Mg-Lu alloy model. In general, the addition of different REEs into Mg could improve its performance from different aspects. This work provides a better understanding on suitable REEs as alloying elements for magnesium, and the future R&D direction on biomedical Mg-RE alloys was proposed.Statement of SignificanceIn contrast to various reports on nutrient elements (Ca, Zn, Sr, etc.) as alloying elements of biomedical magnesium alloys, until now there is limited information about how to choose the right rare earth elements (REEs) as alloying elements of magnesium. In this work, comparative studies were undertaken by individually adding 16 kinds of REEs, including Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Du, Ho, Er, Tm, Yb and Lu, into Mg to fabricate binary Mg-RE model alloys, with different composition points, then the impact of each kind of rare earth element on the microstructure, mechanical property, corrosion behavior and biocompatibility of Mg under the same working history were investigated, and the corresponding influence level for the 16 kinds of REEs were ranked. This work provides a better understanding on suitable REEs as alloying elements for magnesium, and the future R&D direction on biomedical Mg-RE alloys was proposed. (C) 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.