Skin Ulcers and Mortality Among Adolescents and Young Adults With Spina Bifida in South Carolina During 2000-2010.
Skin Ulcers and Mortality Among Adolescents and Young Adults With Spina Bifida in South Carolina During 2000-2010.
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DOI：
10.1177/0883073815596611
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发表时间：
2016-03
影响因子：
1.9
通讯作者：
Ouyang L
中科院分区：
文献类型：
--
作者：
Cai B;McDermott S;Wang Y;Royer JA;Mann JR;Hardin JW;Ozturk O;Ouyang L
作者调查了2000-2010年期间南卡罗来纳州690名青少年和年轻成人脊柱裂患者中的48例死亡（死亡率为7%）。作者使用了医疗补助和其他管理数据以及回顾性队列设计，其中包括使用ICD-9编码识别的脊柱裂患者。构建具有时间依赖性和时间不变协变量的考克斯回归模型和Kaplan-Meier生存曲线。作者发现，在研究期间，研究组中有21.4%的人患有皮肤溃疡，患有皮肤溃疡的人的死亡率明显高于没有溃疡的人（P <0.0001）。在青春期第一次皮肤溃疡的人比那些在青年期第一次皮肤溃疡的人死亡率更高（P = 0.0002;风险比= 10.70，风险比的95%置信区间：3.01，38.00），没有皮肤溃疡，控制其他协变量。这项研究表明，个人首次出现皮肤溃疡的年龄与死亡率有关。
The authors investigated 48 deaths (7% death rate) among 690 adolescents and young adults with spina bifida in South Carolina during 2000–2010. The authors used Medicaid and other administrative data and a retrospective cohort design that included people with spina bifida identified using ICD-9 codes. Cox regression models with time-dependent and time-invariant covariates, and Kaplan–Meier survival curves were constructed. The authors found that 21.4% of the study group had a skin ulcer during the study period and individuals with skin ulcers had significantly higher mortality than those without ulcers (P < .0001). People who had their first skin ulcer during adolescence had higher mortality than those who had the first skin ulcer during young adulthood (P = .0002; hazard ratio = 10.70, 95% confidence interval for hazard ratio: 3.01, 38.00) and those without skin ulcers, controlling for other covariates. This study showed that age at which individuals first had a skin ulcer was associated with mortality.