STRUCTURAL IDENTIFICATION OF THE ANTIBODY-BINDING SITES OF HONG-KONG INFLUENZA HEMAGGLUTININ AND THEIR INVOLVEMENT IN ANTIGENIC VARIATION
STRUCTURAL IDENTIFICATION OF THE ANTIBODY-BINDING SITES OF HONG-KONG INFLUENZA HEMAGGLUTININ AND THEIR INVOLVEMENT IN ANTIGENIC VARIATION
复制标题
DOI：
10.1038/289373a0
复制
发表时间：
1981-01-01
期刊：
影响因子：
64.8
通讯作者：
SKEHEL, JJ
中科院分区：
文献类型：
--
作者：
WILEY, DC;WILSON, IA;SKEHEL, JJ
鉴定了流感血凝素 3 维结构上的四个抗原位点。 1968 年至 1975 年间，每个位点至少需要 1 个氨基酸替换，才能产生新的流行毒株。
Four antigenic sites on the 3 dimensional structure of the influenza hemagglutinin are identified. At least 1 amino acid substitution in each site seems to be required for the production of new epidemic strains between 1968 and 1975.