Aging change of mandibular condyle in female F344/N rat
Aging change of mandibular condyle in female F344/N rat
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DOI：
10.1016/j.archger.2009.07.005
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发表时间：
2010-07-01
影响因子：
4
通讯作者：
Tanaka, Shin
中科院分区：
文献类型：
--
作者：
Nishijima, Kazutoshi;Kuwahara, Sachi;Tanaka, Shin
为了确定实验大鼠是否是口腔衰老研究的合适动物模型，本研究重点研究了下颌骨的形态。对雌性F344/N大鼠下颌骨软骨形态和形态的增龄变化进行了分析。1个月龄(M)大鼠关节软骨可见关节层、增殖细胞层和肥大细胞层，2个月龄大鼠关节软骨细胞层明显扁平，7.7个月及以上大鼠关节软骨可见成熟细胞层。30.9M大鼠关节软骨层紊乱，关节层变薄。随着年龄的增长，髁突矢状面长度逐渐减小，而额面矢状面长度逐渐增大。髁突大小的变化有三个阶段，分别对应于大鼠的生长、衰老和衰老阶段。结果表明，大鼠髁突软骨的退行性改变与人相似，但由于咀嚼方式的不同，其形态变化与人不同。(C)2009爱思唯尔爱尔兰有限公司。保留所有权利。
To ascertain whether laboratory rats represent an adequate animal model for aging oral cavity research, this study focused on the morphology of the mandibular condyle. Aging changes of cartilaginous conformation and shape of the mandibular condyles were analyzed in female F344/N rats. In the condylar cartilage, articular, proliferative cell and hypertrophic cell layers were observed in 1-month-old (M) rat, whereas flattened cell layer was notable at 2 M. A mature cell layer was observed in the condylar cartilage of rats at 7.7 M and over. Deranged cartilaginous layers and thinning articular layer were observed in 30.9 M rat. The sagittal length of the condyle decreased, whereas the frontal one increased with aging and/or age. There were three phases in the transition patterns of the size of the condyle, which seemed to correspond to the respective growing, aging and senescence phases in the rat. The results suggested that degenerative change of condylar cartilage in rat was similar to that in human, whereas change of the shape of the condyle was different between rat and human, caused by a different pattern of mastication. (C) 2009 Elsevier Ireland Ltd. All rights reserved.