Hormonal and nutritional regulation of IGF-I and its binding proteins.
Hormonal and nutritional regulation of IGF-I and its binding proteins.
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IGF-I 及其结合蛋白的激素和营养调节。
DOI：
10.1159/000184187
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Clemmons,DR
中科院分区：
文献类型：
--
作者：
Underwood,LE;Thissen,JP;Lemozy,S;Ketelslegers,JM;Clemmons,DR
营养对生长的影响似乎可能部分通过IGF-I介导。限制膳食营养素对IGF-I的合成和作用有多个步骤的不利影响，包括GH受体减少、GH作用中的受体后缺陷、IGF-I mRNA稳态水平降低和IGF-I作用减弱。此外，营养不良影响IGF结合蛋白的方式各不相同，从一个组织到另一个。了解由营养不足引起的IGFBPs的改变可以提供对IGFBPs作用的深入了解。
The influence of nutrition on growth seems likely to be mediated in part through IGF-I. Restriction of dietary nutrients adversely effects IGF-I synthesis and action at multiple steps, including decreased GH receptors, postreceptor defects in GH action, decreased steady state levels of IGF-I mRNA, and attenuation of IGF-I action. In addition, undernutrition affects the IGF binding proteins in ways that vary from one tissue to another. Understanding the alterations in IGFBPs that are caused by nutritional insufficiency may provide insight into the actions of the IGFBPs.