Wireless Capsule Motility: Comparison of the SmartPillA® GI Monitoring System with Scintigraphy for Measuring Whole Gut Transit
Wireless Capsule Motility: Comparison of the SmartPillA® GI Monitoring System with Scintigraphy for Measuring Whole Gut Transit
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DOI：
10.1007/s10620-009-0899-9
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发表时间：
2009-10-01
影响因子：
3.1
通讯作者：
Friedenberg, Frank K.
中科院分区：
文献类型：
--
作者：
Maqbool, Sabba;Parkman, Henry P.;Friedenberg, Frank K.
通过不透射线标记物或造影术评估整个肠道传输，用于评估便秘患者的胃肠道传输缓慢。使用SmartPill（A（R））GI监测系统的无线胶囊运动性，在胶囊穿过胃肠道时以规则的间隔从胶囊中采样并传输腔内pH、压力和温度数据;从这些数据中，可以评估胃排空和整个胃肠道通过。本研究的目的是比较SmartPill（A（R））和全肠转运造影，以确定SmartPill系统是否可以作为测量全肠运动和转运的测试。10名健康无症状受试者同时接受了全肠转运造影和SmartPill（A（R））评估全肠转运。所有受试者均按照方案完成了研究，并经历了药丸的自然通过。胶囊在胃中的停留时间与120 min（r = 0.95）和240 min（r = 0.73）时Tc-99放射性标记的胃滞留百分比非常密切相关。SmartPill测量的小肠收缩min（-1）与小肠传输%（r = 0.69; P = 0.05）和摄入后24 h的同位素结肠几何中心（r = 0.70，P = 0.024）相关。胶囊通过时间与全肠通过的造影评估相关。SmartPill（A（R））胶囊对胃排空和全肠通过的评估优于造影评估。无线胶囊运动显示出作为一种有用的诊断测试，以评估患者的胃肠道传输障碍和研究促动力剂对胃肠道传输的影响的前景。
Assessment of whole gut transit, by radio-opaque markers or scintigraphy, is used to evaluate patients with constipation for slow gastrointestinal transit. Wireless capsule motility, using the SmartPill(A (R)) GI monitoring system, samples and transmits intraluminal pH, pressure, and temperature data from a capsule at regular intervals as it traverses through the gastrointestinal tract; from these, gastric emptying and whole gastrointestinal tract transit can be assessed. The objective of this study was to compare the SmartPill(A (R)) with whole gut transit scintigraphy to determine whether the SmartPill system could serve as a test for measurement of whole gut motility and transit.Ten healthy, asymptomatic subjects underwent simultaneous whole gut scintigraphy and SmartPill(A (R)) assessment of whole gut transit.All subjects completed the study per protocol and experienced natural passage of the pill. Capsule residence time in the stomach correlated very strongly with percent gastric retention of the Tc-99 radiolabel at 120 min (r = 0.95) and at 240 min (r = 0.73). Small bowel contraction-min(-1) measured by the SmartPill correlated with small bowel transit % (r = 0.69; P = 0.05) and with isotopic colonic geometric center at 24 h after ingestion (r = 0.70, P = 0.024). Capsule transit time correlated with scintigraphic assessment of whole gut transit.SmartPill(A (R)) capsule assessment of gastric emptying and whole gut transit compares favorably with that of scintigraphy. Wireless capsule motility shows promise as a useful diagnostic test to evaluate patients for GI transit disorders and to study the effect of prokinetic agents on GI transit.