Cross-Talk Between Notch and EGFR Signaling in Human Breast Cancer Cells
Cross-Talk Between Notch and EGFR Signaling in Human Breast Cancer Cells
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DOI：
10.1080/07357900802563036
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发表时间：
2009-01-01
影响因子：
2.4
通讯作者：
Ji, Chunyan
中科院分区：
文献类型：
--
作者：
Dai, Jianjian;Ma, Daoxin;Ji, Chunyan
Notch 和表皮生长因子受体 (EGFR) 信号在细胞增殖、分化和凋亡中发挥着关键作用，因此可能有助于乳腺癌的发展。我们在人乳腺癌细胞中组成型过表达活性 Notch1，以探索 Notch1 信号传导对细胞生长的影响并研究潜在的分子机制。我们发现EGFR表达增加。然后，使用EGFR抑制剂，我们发现它对人类乳腺癌细胞表现出抑制作用。 Notch1 的过度表达可以逆转 EGFR 抑制剂诱导的细胞毒性，表明 Notch 和 EGFR 信号传导在人类乳腺癌中可能呈正交联。
Notch and epidermal growth factor receptor (EGFR) signaling play critical roles in cell proliferation, differentiation, and apoptosis, and thereby may contribute to the development of breast cancer. We constitutively overexpressed active Notch1 in human breast cancer cells to explore the consequences of Notch1 signaling on cell growth and to investigate the underlying molecular mechanisms. We found that EGFR expression was increased. Then, using EGFR inhibitor, we found it exhibited an inhibitory role on human breast cancer cells. Overexpression of Notch1 could reverse EGFR inhibitor-induced cell toxicity, suggesting that Notch and EGFR signaling may be positively cross-linked in human breast cancer.