INTESTINAL MICROVILLUS - ULTRASTRUCTURAL VARIABILITY IN CELIAC-DISEASE AND COWS MILK INTOLERANCE
INTESTINAL MICROVILLUS - ULTRASTRUCTURAL VARIABILITY IN CELIAC-DISEASE AND COWS MILK INTOLERANCE
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DOI：
10.1111/j.1651-2227.1976.tb04409.x
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发表时间：
1976-01-01
期刊：
影响因子：
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通讯作者：
ELIAN, E
中科院分区：
文献类型：
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作者：
IANCU, T;ELIAN, E
对8例乳糜泻患者、2例牛奶不耐受患者和10例其他胃肠道疾病患者进行了肠活检，以比较表面微绒毛与隐窝微绒毛（MV）的改变程度。在那些与摄入有毒物质相关的疾病中，即乳糜泻和牛奶不耐受，注意到严重受损的表面上皮及其MV与保存的隐窝上皮之间存在显著和突然的差异。这些形态学变化可能是由于与伸长的隐窝中较低的醇溶蛋白或乳蛋白浓度相反，在avillous表面上皮上较高的醇溶蛋白或乳蛋白浓度引起的。
In 8 patients with celiac disease, 2 patients with cow''s milk intolerance and 10 patients with other gastrointestinal disturbances, intestinal biopsies were examined to compare the extent of alteration of surface vs. crypt microvilli (MV). In those diseases associated with the ingestion of a noxious agent, namely celiac disease and cow''s milk intolerance, a marked and abrupt difference between the severely damaged surface epithelium and its MV and the preserved crypt epithelium was noted. These morphological variations possibly are caused by the higher gliadin or milk protein concentration over the avillous surface epithelium as opposed to the lower one in the elongated crypts.