State of the art in development of molecularly imprinted biosensors
State of the art in development of molecularly imprinted biosensors
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DOI：
10.1002/viw.20200170
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发表时间：
2021-07
期刊：
影响因子：
8.6
通讯作者：
Licheng Wu;Xiaolei Li;Haohan Miao;Jingjing Xu;G. Pan
中科院分区：
文献类型：
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作者：
Licheng Wu;Xiaolei Li;Haohan Miao;Jingjing Xu;G. Pan
生物传感器是一类用于目标分析物检测的智能设备。生物传感器通常由三个基本部件组成：特定的生物感受器、物理化学传感器和信号处理装置。生物感受器部分的特点是生物传感器执行特定分析物检测的较关键技术之一。它们通常利用各种分子识别元件，如酶、天然受体、抗体、核酸适配子，甚至合成受体。然后，这些生物受体的分子识别事件可以转化为各种形式的可读信号，如电化学、光学、压电/热释电等。最后，对这些信号进行数学处理，进行定量分析。目前，仿生材料，特别是基于分子印迹聚合物(MIP)的合成受体的巨大进步，推动了生物传感器的巨大发展。该领域与人工智能的结合使先进生物传感器的新兴设计成为可能，这一设计已经从概念走向实施，同时也面临着新的机遇和挑战。基于分子印迹的生物感受器创新无疑是生物传感器发展的新动力。在这篇综述文章中，我们提供了基于MIP的生物传感器的概述，并讨论了它们在可穿戴设备方面的挑战和机遇。
Biosensors are a class of smart devices fabricated for target analyte detection. A biosensor is commonly made of three basic components: a specific bioreceptor, a physicochemical transducer, and a signal processing device. The bioreceptor part features one of the more crucial technologies of a biosensor to perform specific detection of analytes. They commonly make use of various molecular recognition elements, such as enzymes, natural receptors, antibodies, nucleic acid aptamers, and even synthetic receptors. Then, the molecular recognition events of these bioreceptors can be translated into readable signals in various forms like electrochemical, optical, piezo/pyro electric, etc. Finally, these signals are mathematically processed for quantitative analysis. Nowadays, the great advances in biomimetic materials, in particular the synthetic receptors based on molecularly imprinted polymers (MIPs), promote tremendous development of biosensors. Integration of this field with artificial intelligence enables emerging design of advanced biosensors, which has moved from concept to implementation, meanwhile facing new opportunities and challenges. With no doubt, bioreceptor innovation based on molecular imprinting is an emerging driving force for biosensors development. In this review paper, we provide an overview of MIP‐based biosensors, and also their challenges and opportunities moving forward toward wearable devices are discussed.