The kidney and planar cell polarity.
The kidney and planar cell polarity.
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DOI：
10.1016/b978-0-12-394592-1.00011-9
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发表时间：
2012
影响因子：
--
通讯作者：
Yu J
中科院分区：
文献类型：
--
作者：
Carroll TJ;Yu J
平面细胞极性（PCP）或组织极性描述组织平面上的协调极性，其中组织内大多数或所有细胞在一个方向上极化。它垂直于细胞的顶基极性。PCP在果蝇的翅膀和角质层刚毛、果蝇的眼小眼、哺乳动物的毛发和内耳毛束中很容易表现出来，而在细胞过程中，如协调的、定向的细胞运动和定向的细胞分裂中则不太明显，这些细胞过程对组织形态发生很重要。几个不同的分子和细胞过程涉及PCP的调节。在这里，我们回顾了PCP在小鼠肾脏发育和维持过程中的潜在作用，包括输尿管芽分支形态的形成、肾髓质的延长、小管直径的建立/维持、肾小球的形成和对损伤的反应。讨论了这些过程的潜在机制，包括定向细胞分裂和协调细胞迁移/细胞嵌入。此外，我们还讨论了与肾脏PCP相关的一些尚未解决的研究课题，希望能促进进一步的讨论和研究。
Planar cell polarity (PCP) or tissue polarity describes a coordinated polarity at the plane of the tissue where most or all cells within a tissue are polarized in one direction. It is perpendicular to the apical–basal polarity of the cell. PCP is manifested readily in the Drosophila wing and cuticle bristles, Drosophila eye ommatidia, and mammalian hair and inner ear hair bundles, and less evidently, in cellular processes such as in the coordinated, directional cell movements, and oriented cell divisions that are important for tissue morphogenesis. Several distinct molecular and cellular processes have been implicated in the regulation of PCP. Here, we review potential roles for PCP during mouse kidney development and maintenance, including ureteric bud branching morphogenesis, renal medulla elongation, tubule diameter establishment/maintenance, glomerulogenesis, and response to injury. The potential mechanisms underlying these processes, including oriented cell division and coordinated cell migration/cell intercalation, are discussed. In addition, we discuss some unaddressed research topics related to PCP in the kidney that we hope will spur further discussion and investigation.