Copper(I) hydride-catalyzed asymmetric hydrosilylation of heteroaromatic ketones
Copper(I) hydride-catalyzed asymmetric hydrosilylation of heteroaromatic ketones
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DOI：
10.1021/ol026755n
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发表时间：
2002-11-14
期刊：
影响因子：
5.2
通讯作者：
Noson, K
中科院分区：
文献类型：
--
作者：
Lipshutz, BH;Lower, A;Noson, K
通过Takasago的新的非外消旋配体DTBM-SEGPHOS连接的CuH的原位生成导致能够在非常温和的条件下实现杂芳族（H）酮的不对称氢化硅烷化的特别反应性试剂。PMHS是一种廉价的氢化物来源。采用2000：1量级的底物与配体比率。
[GRAPHICS]In situ generation of CuH ligated by Takasago's new nonracemic ligand, DTBM-SEGPHOS, leads to an especially reactive reagent capable of effecting asymmetric hydrosilylation of heteroaromatic (H) ketones under very mild conditions. PMHS serves as an inexpensive source of hydride. Substrate-to-ligand ratios on the order of 2000:1 are employed.