Degradation of amoxicillin in composting toilet
Degradation of amoxicillin in composting toilet
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发表时间：
2006
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通讯作者：
T. Kakimoto;N. Funamizu
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作者：
T. Kakimoto;N. Funamizu
研究了粪便堆肥过程中影响阿莫西林降解的生物和非生物因素。我们首先研究了活细菌和酶(β-内酰胺酶)对阿莫西林腐烂的生物学效应，我们的结果表明，生物学效应可能可以忽略不计。因此，我们通过监测阿莫西林在几个pH水平的磷酸盐和氨缓冲液中的还原速率，考察了磷酸盐、氨和pH水平作为非生物因素对阿莫西林的影响。通过一个模拟模型对每个还原速率常数进行积分，并将计算的阿莫西林还原曲线与阿莫西林在粪便堆肥过程中的还原曲线进行比较。计算结果与实验曲线几乎完全吻合。因此，我们得出结论，阿莫西林在厕所基质中的降解依赖于氨、磷和羟基离子的浓度。对示范植物基质中的磷酸盐、氨和pH水平进行了监测，既然我们发现它们的浓度增加了，我们应该能够预见阿莫西林在厕所里的腐烂。
We have investigated the biological and non-biological factors that affect the degradation of amoxicillin in the composting process of feces. We first examined the biological effect of living bacteria and the enzyme (beta-lactamase) on amoxicillin decay, and our results indicated that the biological effects are likely to be negligible. Consequently, we investigated the effect of phosphate and ammonia and pH level as non-biological factors by monitoring the reduction rate of amoxicillin in phosphate and ammonia buffer solutions with several pH levels. Each reduction rate constant was integrated by a simulation model, and the calculated amoxicillin reduction profile was compared to the reduction profiles of amoxicillin in the composting process of feces. The calculated results corresponded almost exactly to the experimental profiles. We therefore concluded that the degradation of amoxicillin in a toilet matrix was dependent on the concentration of ammonia, phosphate and hydroxyl ion. The phosphate and ammonia and pH level in the demonstration plant matrix were monitored, and since we found that their concentration increased, we should be able to expect the decay of amoxicillin in a toilet.