Timing of birth and risk of multiple sclerosis: population based study.
Timing of birth and risk of multiple sclerosis: population based study.
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DOI：
10.1136/bmj.38301.686030.63
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发表时间：
2005-01-15
影响因子：
105.7
通讯作者：
Ebers, GC
中科院分区：
文献类型：
--
作者：
Willer, CJ;Dyment, DA;Ebers, GC
目的为了确定多发性硬化症（MS）的风险是否与出生月份在北方半球的国家，如果与出生月份相关的因素与遗传risk.Design人口为基础的研究与人口和家庭为基础的控制和一个回顾性队列确定从死亡证明。对包括瑞典和丹麦在内的大型北方数据集进行了事后汇总分析。（加拿大关于多发性硬化症遗传易感性的合作项目）;来自苏格兰洛锡安和边境地区基于人群的研究的MS事件病例; 17874名加拿大患者和11502名英国多发性硬化患者。主要结果测量多发性硬化的诊断。结果在加拿大（n = 17874）与来自人口普查的对照组和未受影响的兄弟姐妹相比，11月出生的MS患者显著较少。这些观察结果在英国患者（n = 11502）的数据集中得到了证实，其中5月份的出生人数也有所增加。对来自加拿大、英国、丹麦和瑞典（n = 42 045）的数据集的汇总分析显示，11月出生的MS患者明显较少（805%），5月出生的MS患者明显较多（9.1%）。对于最近的事件数据，出生月份的影响是最明显的，在苏格兰，MS患病率是highest.Conclusions月份的出生和MS的风险是相关的，更是在家族性的情况下，这意味着基因和环境之间的相互作用，是与气候。在所研究的北方国家出生的个体中，这种相互作用可能发生在妊娠期间或出生后不久。
Objectives To determine if risk of multiple sclerosis (MS) is associated with month of birth in countries in the northern hemisphere and if factors related to month of birth interact with genetic risk.Design Population based study with population and family based controls and a retrospective cohort identified from death certificates. A post hoc pooled analysis was carried out for large northern datasets including Sweden and Denmark.Setting 19 MS clinics in major cities across Canada (Canadian collaborative project on the genetic susceptibility to multiple sclerosis); incident cases of MS from a population based study in the Lothian and Border regions of Scotland; and death records from the UK Registrar General.Populations 17 874 Canadian patients mid 11 502 British patients with multiple sclerosis.Main outcome measure Diagnosis of multiple sclerosis.Results In Canada (n = 17 874) significantly fewer patients with MS Were born in November compared with controls from the population census and unaffected siblings. These observations were confirmed in a dataset of British patients (n = 11502), in which there was also an increase in the number of births in May. A pooled analysis of datasets from Canada, Great Britain, Denmark, and Sweden (n = 42 045) showed that significantly fewer (805%) people with MS were born in November mid significantly more (9.1%) were born in May. For recent incident data, the effect of month of birth was most evident in Scotland, where MS prevalence is the highest.Conclusions Month of birth and risk of MS are associated, more so in familial cases, implying interactions between genes and environment that are related to climate. Such interactions may act during gestation or shortly after birth in individuals born in the northern countries studied.