Seborrheic Dermatitis and Dandruff: A Comprehensive Review.
Seborrheic Dermatitis and Dandruff: A Comprehensive Review.
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DOI：
10.13188/2373-1044.1000019
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发表时间：
2015-12
期刊：
影响因子：
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通讯作者：
Wikramanayake TC
中科院分区：
文献类型：
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作者：
Borda LJ;Wikramanayake TC
脂溢性皮炎 (SD) 和头皮屑是影响身体脂溢区域的同一疾病的连续谱。头皮屑仅限于头皮，皮肤发痒、剥落，但没有明显的炎症。 SD 会影响头皮以及其他脂溢区域，并导致皮肤发痒、剥落或鳞屑、炎症和瘙痒。各种内在和环境因素，如皮脂分泌、皮肤表面真菌定植、个体易感性以及这些因素之间的相互作用，都有助于 SD 和头皮屑的发病机制。在这篇综述中，我们总结了当前关于 SD 和头皮屑的知识，包括流行病学、疾病负担、临床表现和诊断、治疗、人类和动物模型的遗传学研究以及诱发因素。动物模型中的遗传和生化研究以及调查为病理生理学和更好的治疗策略提供了进一步的见解。
Seborrheic Dermatitis (SD) and dandruff are of a continuous spectrum of the same disease that affects the seborrheic areas of the body. Dandruff is restricted to the scalp, and involves itchy, flaking skin without visible inflammation. SD can affect the scalp as well as other seborrheic areas, and involves itchy and flaking or scaling skin, inflammation and pruritus. Various intrinsic and environmental factors, such as sebaceous secretions, skin surface fungal colonization, individual susceptibility, and interactions between these factors, all contribute to the pathogenesis of SD and dandruff. In this review, we summarize the current knowledge on SD and dandruff, including epidemiology, burden of disease, clinical presentations and diagnosis, treatment, genetic studies in humans and animal models, and predisposing factors. Genetic and biochemical studies and investigations in animal models provide further insight on the pathophysiology and strategies for better treatment.