Bacterial communication ("Quorum sensing") via ligands and receptors: A novel pharmacologic target for the design of antibiotic drugs
Bacterial communication ("Quorum sensing") via ligands and receptors: A novel pharmacologic target for the design of antibiotic drugs
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DOI：
10.1124/jpet.104.075150
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发表时间：
2005-02-01
影响因子：
3.5
通讯作者：
Young, JM
中科院分区：
文献类型：
--
作者：
Raffa, RB;Iannuzzo, JR;Young, JM
本展望的目的是提出一个关于细菌的“群体感应”的文献的概要，作为一个背景的建议，干扰这种通信系统提供了潜在的目标，设计新的抗生素药物。群体感应是最近发现的革兰氏阳性菌和革兰氏阴性菌之间的化学通讯系统。它对于细菌内和细菌间的基因调控以及保持细菌菌落（“生物膜”）完整至关重要，允许常驻细菌承担有助于提高群体生存的专门角色。有几个过程涉及药理学家熟悉的群体感应;即，特异性信号分子结合并激活受体，所述受体将群体感应信号转化为细胞内第二信使应答。我们在此强调群体感应通信与配体-受体相互作用之间的相似性，这表明可以使用当前标准的药理学原理设计抑制剂药物。这些药物将具有新的作用机制，因此可能对耐药菌株更有效。
The purpose of the present Perspectives is to present a synopsis of the literature on bacterial "quorum sensing" as a background for the proposal that interference with this communication system offers potential targets for the design of novel antibiotic drugs. Quorum sensing is the recently discovered chemical communication system among bacteria ( both Gram-positive and - negative). It is vital for intra- and interbacterial gene regulation and for keeping bacterial colonies ("biofilms") intact, allowing resident bacteria to assume specialized roles that contribute to enhanced survival of the group. There are several processes involved in quorum sensing that are familiar to pharmacologists; i.e., specific signaling molecules bind to and activate receptors that transduce the quorum-sensing signal into intracellular second messenger responses. We highlight herein the similarity between quorum-sensing communication to ligand-receptor interactions, suggesting that inhibitor drugs could be designed using current standard pharmacologic principles. Such drugs would have novel mechanisms of action and might therefore be more effective against antibiotic-resistant strains of bacteria.