Body iron excretion by healthy men and women
Body iron excretion by healthy men and women
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DOI：
10.3945/ajcn.2009.27439
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发表时间：
2009-06-01
影响因子：
7.1
通讯作者：
Johnson, LuAnn K.
中科院分区：
文献类型：
--
作者：
Hunt, Janet R.;Zito, Carol Ann;Johnson, LuAnn K.
背景：通过同位素稀释法测量的铁排泄量一直是因子推导铁摄入量建议的主要依据，但结果仅适用于男性。目的：本研究的目的是确认健康男性的铁排泄量，并将其推广到女性。设计：根据社区53名受试者每半年采集一次的血液样本，确定早些时候服用>；=1年的(55)Fe的周转率。通过血红蛋白、血清铁蛋白和转铁蛋白受体测定体内铁。结果：男性总排铁量中位数为1.18(0.11~2.07)mg/d，19名经期女性为1.58(0.65~4.88)mg/d，5名绝经后女性为0.99(0.86~1.57)mg/d。当不使用激素避孕药时，15名月经妇女的中位数增加到1.66 mg/d。男性和绝经后妇女的铁排泄分布是正常的，而经期妇女的分布是高度偏斜的，月经期的铁可以解释90%的变异。铁的排泄量与体重没有很强的相关性。月经期女性体内的铁在男性中有所下降(4.6%)，在研究过程中趋于上升(1.5%)。结论：结果扩展了男性的直接铁排泄量测量，包括女性的类似测量。这些结果强调了人体铁的排泄范围很广，这导致对吸收的铁的需求量增加了40倍。这项试验在Clinicaltrials.gov上注册为NCT00755105。AM J Clin Nutr 2009；89：1792-8。
Background: Iron excretion measured by isotope dilution has been a primary basis for the factorial derivation of recommendations for iron intake, but the results have been available for men only.Objective: The objective of this study was to confirm iron excretion measurements in healthy men and extend them to women.Design: The turnover rate of (55)Fe that had been administered >= 1 y earlier was determined from blood sampled semiannually for up to 3 y from 53 subjects in the community. Body iron was determined from hemoglobin, serum ferritin, and transferrin receptor. Complete menstrual collections were obtained from 13 women.Results: The total median (range) iron excretion was 1.18 (0.11-2.07) mg/d for 29 men, 1.58 (0.65-4.88) mg/d for 19 menstruating women, and 0.99 (0.86-1.57) for 5 postmenopausal women. When hormonal contraceptive users were omitted, the median for 15 menstruating women increased to 1.66 mg/d. The distribution of iron excretion was normal for the men and postmenopausal women and was highly skewed for the menstruating women; menstrual iron accounted for 90% of the variation. Iron excretion was not strongly related to body weight. Body iron in menstruating women decreased somewhat (by 4.6%) in the men and tended to increase (by 1.5%) during the study.Conclusions: The results extend direct iron excretion measurements in men to include similar measurements in women. The results emphasize the wide range of iron excretion in humans, which results in a 40-fold range of requirements for absorbed iron. This trial was registered at clinicaltrials.gov as NCT00755105. Am J Clin Nutr 2009; 89: 1792-8.