New trends in cannabis potency in USA and Europe during the last decade (2008-2017)
New trends in cannabis potency in USA and Europe during the last decade (2008-2017)
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DOI：
10.1007/s00406-019-00983-5
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发表时间：
2019-02-01
影响因子：
4.7
通讯作者：
ElSohly, Mahmoud A.
中科院分区：
文献类型：
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作者：
Chandra, Suman;Radwan, Mohamed M.;ElSohly, Mahmoud A.
通过密西西比大学由国家药物滥用研究所(NIDA)支持的效力监测计划，在过去十年中，总共使用经过验证的GC/FID方法分析了18108个大麻制剂样本。这些样本被归类为辛塞米拉、大麻、杂草、大麻和大麻油(现在被称为大麻浓缩油)。由于美国许多州将用于医疗或娱乐目的的大麻合法化，过去5年收到的样本数量大幅减少。结果表明，Delta(9)-THC的平均浓度在过去10年里急剧增加，从2008年的8.9%上升到2017年的17.1%。Delta(9)-THC：CBD的平均比率也从2008年的23大幅上升至2017年的104。从2008年到2017年，查获的大麻油样本(浓缩物)的比例(0.5%-4.7%)及其Delta(9)-THC的平均浓度(6.7%-55.7%)也显著增加。荷兰、英国、法国和意大利等几个欧洲国家也有其他效力监测计划。这些方案还记录了大麻中Delta(9)-THC浓度和Delta(9)-THC：CBD比率的增加。过去十年的这些趋势表明，在美国和欧洲，大麻正在成为一种日益有害的产品。
Through the potency monitoring program at the University of Mississippi supported by National Institute on Drug Abuse (NIDA), a total of 18108 samples of cannabis preparations have been analyzed over the last decade, using a validated GC/FID method. The samples are classified as sinsemilla, marijuana, ditchweed, hashish, and hash oil (now referred to as cannabis concentrate). The number of samples received over the last 5 years has decreased dramatically due to the legalization of marijuana either for medical or for recreational purposes in many US states. The results showed that the mean Delta(9)-THC concentration has increased dramatically over the last 10 years, from 8.9% in 2008 to 17.1% in 2017. The mean Delta(9)-THC:CBD ratio also rose substantially from 23 in 2008 to 104 in 2017. There was also marked increase in the proportion of hash oil samples (concentrates) seized (0.5-4.7%) and their mean Delta(9)-THC concentration (6.7-55.7%) from 2008 to 2017. Other potency monitoring programs are also present in several European countries such as The Netherlands, United Kingdom, France, and Italy. These programs have also documented increases in Delta(9)-THC concentrations and Delta(9)-THC:CBD ratios in cannabis. These trends in the last decade suggest that cannabis is becoming an increasingly harmful product in the USA and Europe.