Diabetes is most important cause for mortality in COVID-19 hospitalized patients: Systematic review and meta-analysis.
Diabetes is most important cause for mortality in COVID-19 hospitalized patients: Systematic review and meta-analysis.
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DOI：
10.1007/s11154-021-09630-8
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发表时间：
2021-06
影响因子：
8.2
通讯作者：
Maggi M
中科院分区：
文献类型：
--
作者：
Corona G;Pizzocaro A;Vena W;Rastrelli G;Semeraro F;Isidori AM;Pivonello R;Salonia A;Sforza A;Maggi M
2020 年 2 月底，欧洲正式记录了 SARS-CoV-2 的存在。尽管进行了许多观察，但 COVID-19 在欧盟 (EU) 的真正影响、其潜在因素及其对死亡率和发病结果的影响从未得到系统调查。本工作的目的是对住院患者严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染相关死亡率 (MR) 的主要预测因素和国家差异进行概述和荟萃分析。在 3714 篇检索到的文章中，考虑了 87 项研究，包括 35,486 名患者（平均年龄 60.9±8.2 岁）和 5867 例死亡。调整混杂因素后，糖尿病是 MR 的最佳预测因子，且与年龄和性别相关，其次是慢性肺阻塞性疾病和恶性肿瘤。在美国和欧洲，MR 均高于亚洲报告的水平（25[20;29]% 和 20[17;23]% vs. 13[10;17]%；均 p<0.02）。在临床参数中，呼吸困难、疲劳和肌痛以及呼吸频率成为 MR 的最佳预测因子。最后，淋巴细胞和血小板计数减少以及 D-二聚体水平增加，均显着导致死亡率增加。血糖曲线的优化以及适当的血栓并发症预防策略必须成为 SARS-CoV-2 感染患者的常规做法。在线版本包含可在 10.1007/s11154-021-09630-8 获取的补充材料。
The presence of SARS-CoV-2 was officially documented in Europe at the end of February 2020. Despite many observations, the real impact of COVID-19 in the European Union (EU), its underlying factors and their contribution to mortality and morbidity outcomes were never systematically investigated. The aim of the present work is to provide an overview and a meta-analysis of main predictors and of country differences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-associated mortality rate (MR) in hospitalized patients. Out of 3714 retrieved articles, 87 studies were considered, including 35,486 patients (mean age 60.9 ± 8.2 years) and 5867 deaths. After adjustment for confounders, diabetes mellitus was the best predictors of MR in an age- and sex-dependent manner, followed by chronic pulmonary obstructive diseases and malignancies. In both the US and Europe, MR was higher than that reported in Asia (25[20;29] % and 20[17;23] % vs. 13[10;17]%; both p < 0.02). Among clinical parameters, dyspnea, fatigue and myalgia, along with respiratory rate, emerged as the best predictors of MR. Finally, reduced lymphocyte and platelet count, along with increased D-dimer levels, all significantly contributed to increased mortality. The optimization of glucose profile along with an adequate thrombotic complications preventive strategy must become routine practice in diseased SARS-CoV-2 infected patients. The online version contains supplementary material available at 10.1007/s11154-021-09630-8.
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影响因子：
3.1
作者：
Chilimuri, Sridhar;Sun, Haozhe;Nayudu, Suresh K.
通讯作者：
Nayudu, Suresh K.
影响因子：
2.9
作者：
Claudia, Gregoriano;Daniel, Koch;Philipp, Schuetz
通讯作者：
Philipp, Schuetz
影响因子：
24.5
作者：
Bezzio, Cristina;Saibeni, Simone;Fiorino, Gionata
通讯作者：
Fiorino, Gionata
影响因子：
19.6
作者：
Cheng, Yichun;Luo, Ran;Xu, Gang
通讯作者：
Xu, Gang
DOI：
10.1001/jama.289.21.joc30885
发表时间：
2003-06-04
影响因子：
120.7
作者：
Booth, CM;Matukas, LM;Detsky, AS
通讯作者：
Detsky, AS