CYTOKINES PREDICT CORONARY ANEURYSM FORMATION IN KAWASAKI-DISEASE PATIENTS
CYTOKINES PREDICT CORONARY ANEURYSM FORMATION IN KAWASAKI-DISEASE PATIENTS
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DOI：
10.1007/bf01956740
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发表时间：
1993-04-01
影响因子：
3.6
通讯作者：
CHIANG, BN
中科院分区：
文献类型：
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作者：
LIN, CY;LIN, CC;CHIANG, BN
在这项研究中，我们连续测量了60例川崎病（KD）患者血清中白细胞介素-6 （IL-6）、IL-8、可溶性IL-2受体（sIL-2R）和肿瘤坏死因子α (tnf - α)的水平，并评估了这些细胞因子在预测冠状动脉瘤形成中的临床意义。60例患者中，12例合并冠状动脉瘤。发热后1周内采血，第1个月每周采血1次，后5个月每月采血1次。采用ELISA或RIA法检测血清IL-6、IL-8、sIL-2R和TNFalpha水平。结果表明，血清IL-6和IL-8的变化比sl - 2r和TNFalpha的变化更快。1周内，有冠状动脉瘤患者血清IL-6、IL-8水平明显高于无冠状动脉瘤患者（P < 0.001）。血清IL-6、IL-8水平与c反应蛋白、红细胞沉降率高度相关（P < 0.001）， il - 2r、TNFalpha水平也在第1周升高，第2周达到最高水平。第2周，有冠状动脉瘤患者血清sIL-2R、TNFalpha水平明显高于无冠状动脉瘤患者（P < 0.05）。这些结果提示，在最后一周获得的血清IL-6和IL-8水平可以作为预测KD患者冠状动脉瘤形成的有用参数。
In this study, we measured serially the serum levels of cytokines including interleukin-6 (IL-6), IL-8, soluble IL-2 receptor (sIL-2R) and tumour necrosis factor alpha (TNF-alpha) in 60 patients with Kawasaki disease (KD) and evaluated the clinical significance of these cytokines in predicting coronary aneurysm formation. Of the 60 patients, 12 were complicated with coronary aneurysm. Blood samples were collected within the 1st week after onset of fever, then once a week for the 1st month, and once a month for another 5 months. The serum levels of IL-6, IL-8, sIL-2R and TNFalpha were measured using an ELISA or RIA method. Our results show that the changes in serum IL-6 and IL-8 were faster than those of sl L-2R and TNFalpha. Within the 1st week, the serum levels of IL-6 and IL-8 were significantly higher in the patients with than in those without coronary aneurysm (P < 0.001). In addition, the serum levels of IL-6 and IL-8 obtained in the 1st week were highly correlated (P < 0.001) with those of C-reactive protein and erythrocyte sedimentation rate, and the serum levels of sIL-2R and TNFalpha were also increased at the 1st week reaching the highest level in the 2nd week. In the 2nd week, the serum levels of sIL-2R and TNFalpha were significantly higher in the patients with than in those without coronary aneurysm (P < 0.05). These findings suggest that the serum levels of IL-6 and IL-8 obtained in the lst week may serve as useful parameters in predicting coronary aneurysm formation in KD patients.