THE FUNCTIONAL CAPACITY OF HYPERTROPHIED NEPHRONS
THE FUNCTIONAL CAPACITY OF HYPERTROPHIED NEPHRONS
复制标题
肥大的肾单位的功能能力
DOI：
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发表时间：
1966
影响因子：
15.3
通讯作者：
R. M. Howard
中科院分区：
文献类型：
--
作者：
A. Morrison;R. M. Howard
描述了一种用于测量大鼠中菊粉和PAH清除率而不杀死动物的方法。菊糖清除率测量部分肾切除大鼠和假手术对照组大鼠手术前和手术后的间隔;菊糖清除率测定正常大鼠在其生长过程中的间隔。在另一系列的部分肾切除大鼠和他们的假手术的控制，菊粉和PAH清除率在所有的动物之前，并在手术后的时间间隔。在一些大鼠中进行肾小球计数。在肾部分切除术后，菊糖清除率降低，但考虑到切除的肾组织量，其降低程度不如预期。与对照大鼠相比，部分肾切除大鼠的平均菊糖清除率大大增加。部分肾切除大鼠的菊糖清除率显示出进行性下降，这在手术后约6个月首次明显。假手术大鼠表现出菊糖清除率略低于非手术对照约24至30周后的操作。在正常大鼠中，平均体重为197 ± 3 g的大鼠中相对于体重的菊糖清除率比年龄较大且较重的正常大鼠大得多。部分肾切除大鼠的PAH降低手术后，但在随后的24周内没有进一步的变化。
A method is described for the measurement of inulin and PAH clearances in rats without killing the animal. Inulin clearance measurements of partially nephrectomized rats and sham-control rats were made before operation and at intervals following the operation; inulin clearances were determined on normal rats at intervals during their growth. In another series of partially nephrectomized rats and their sham-operated controls, inulin and PAH clearances were determined in all the animals before and at intervals following the operation. Glomerular counts were made in some rats. After partial nephrectomy the inulin clearance is reduced but not as much as would be expected considering the amount of renal tissue removed. The mean inulin clearance per nephron is greatly increased in the partially nephrectomized rat when compared to the value determined for the control rat. The inulin clearance of the partially nephrectomized rat shows a progressive decline which is first clearly evident about 6 months after operation. The sham-operated rats showed an inulin clearance slightly less than that of nonoperated controls about 24 to 30 wk after the operation. In the normal rats the inulin clearance relative to body weight is much greater in rats with a mean weight of 197 ± 3 g than in normals which are older and heavier. The PAH dearance of the partially nephrectomized rat is reduced following operation but undergoes no further change in the ensuing 24 wk.