The BH3-mimetic GX15-070 induces autophagy, potentiates the cytotoxicity of carboplatin and 5-fluorouracil in esophageal carcinoma cells
The BH3-mimetic GX15-070 induces autophagy, potentiates the cytotoxicity of carboplatin and 5-fluorouracil in esophageal carcinoma cells
复制标题
BH3 模拟物 GX15-070 诱导自噬，增强卡铂和 5-氟尿嘧啶在食管癌细胞中的细胞毒性
DOI：
10.1016/j.canlet.2010.01.006
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发表时间：
2010-07-28
期刊：
影响因子：
9.7
通讯作者：
Cao, Qi
中科院分区：
文献类型：
--
作者：
Pan, Jingxuan;Cheng, Chao;Cao, Qi
尽管手术技术和放疗及化疗方案都有所改进，食管癌的预后仍很差。为了寻求新的有效策略，本研究考察了bh3 -拟合物GX15-070对食管癌细胞的作用。我们发现GX15-070抑制食管癌细胞的生长。GX15-070与卡铂或5-氟尿嘧啶有协同作用。GX15-070诱导食管癌细胞株EC9706和骨肉瘤细胞株U2OS细胞自噬。3-甲基腺嘌呤和氯喹这两种自噬抑制剂作用机制不同，增强了GX15-070的细胞毒性。综上所述，GX15-070具有抑制食管癌细胞生长的作用。2010爱思唯尔爱尔兰有限公司版权所有。
Despite improvements in both surgical techniques and radio- and chemo-therapy regimens, the prognosis of esophageal cancer is poor. In pursuit of novel effective strategy, this study examined the effect of the BH3-mimetic GX15-070 on esophageal carcinoma cells. We discovered that GX15-070 inhibited the growth of esophageal cancer cells. There was synergism between GX15-070 and carboplatin or 5-fluorouracil. GX15-070 induced autophagy in esophagus cancer cell line EC9706 and osteosarcoma cancer cell line U2OS. 3-methyladenine and chloroquine, inhibitors of autophagy with distinct mechanisms, potentiated the cytotoxicity of GX15-070. In conclusion, GX15-070 inhibits growth of esophageal cancer cells. (C) 2010 Elsevier Ireland Ltd. All rights reserved.