Staphylococcus aureus Colonization of the Human Nose and Interaction with Other Microbiome Members
Staphylococcus aureus Colonization of the Human Nose and Interaction with Other Microbiome Members
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DOI：
10.1128/microbiolspec.gpp3-0029-2018
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发表时间：
2019-03-01
影响因子：
3.7
通讯作者：
Krismer, Bernhard
中科院分区：
文献类型：
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作者：
Laux, Claudia;Peschel, Andreas;Krismer, Bernhard
金黄色葡萄球菌通常被认为是一种细菌病原体，因为它能够引起多种类型的侵袭性感染。然而，金黄色葡萄球菌在约 30% 的人群中无症状地寄生在鼻孔中，无论是短暂的还是持续的，因此也可以被视为人类共生体，尽管携带会增加感染的风险。尽管感染过程的许多方面已经得到深入研究，但人们对金黄色葡萄球菌的共生生活方式知之甚少。最近的研究强调了高度可变的鼻腔微生物群的组成在促进或抑制金黄色葡萄球菌定植中的主要作用。对有限营养物质、微量元素和上皮附着位点的竞争、对宿主防御分子的不同敏感性以及细菌竞争者产生的抗菌分子可能决定鼻细菌是否能够相互竞争。本章总结了我们对金黄色葡萄球菌用于有效鼻腔定植的机制以及其他鼻腔细菌干扰其定植的策略的了解。对自然进化机制的更好理解可能使我们能够制定根除病原体的新策略。
Staphylococcus aureus is usually regarded as a bacterial pathogen due to its ability to cause multiple types of invasive infections. Nevertheless, S. aureus colonizes about 30% of the human population asymptomatically in the nares, either transiently or persistently, and can therefore be regarded a human commensal as well, although carriage increases the risk of infection. Whereas many facets of the infection processes have been studied intensively, little is known about the commensal lifestyle of S. aureus. Recent studies highlight the major role of the composition of the highly variable nasal microbiota in promoting or inhibiting S. aureus colonization. Competition for limited nutrients, trace elements, and epithelial attachment sites, different susceptibilities to host defense molecules and the production of antimicrobial molecules by bacterial competitors may determine whether nasal bacteria outcompete each other. This chapter summarizes our knowledge about mechanisms that are used by S. aureus for efficient nasal colonization and strategies used by other nasal bacteria to interfere with its colonization. An improved understanding of naturally evolved mechanisms might enable us to develop new strategies for pathogen eradication.