Prevention of shock wave-induced renal oxidative stress by melatonin: an experimental study
Prevention of shock wave-induced renal oxidative stress by melatonin: an experimental study
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DOI：
10.1007/s00240-003-0397-z
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发表时间：
2004-01
影响因子：
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通讯作者：
T. A. Serel;Fehmi Özguner;S. Soyupek
中科院分区：
文献类型：
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作者：
T. A. Serel;Fehmi Özguner;S. Soyupek
我们的目的是评价内源性自由基清除剂褪黑素对体外冲击波碎石术（ESWL）引起的肾损害的影响。使用30只家兔进行研究，将其分为两组。两组都暴露在18千伏的3,000次冲击波中。第一组动物用褪黑激素处理8天。体外冲击波碎石术后一周处死对照组和褪黑素治疗组家兔。MDA、尿酸和白色细胞计数被用作氧化应激的标志物。褪黑素治疗组的尿酸和白色细胞计数的平均水平显著低于对照组。与对照组相比，褪黑激素治疗组的MDA平均水平也显著降低。我们的研究结果表明，褪黑激素可能表现出保护作用的自由基介导的氧化损伤的体外冲击波碎石术在兔肾脏。
Our aim was to evaluate the effects of the potent endogenous free radical scavenger melatonin on extracorporeal-shock-wave lithotripsy (ESWL) induced renal impairment. The study was performed using 30 rabbits which were divided into two groups. Both groups were exposed to 3,000 shock waves at 18 Kv. The animals in the first group were treated with melatonin for 8 days. Controls and melatonin treated rabbits were killed a week after ESWL. MDA, uric acid and white cell counts were used as markers of oxidative stress. The mean levels of uric acid and white cell counts were significantly lower in the melatonin treated group than in the controls. The mean level of MDA was also significantly lower in the melatonin treated group compared to the controls. Our results show that melatonin may exhibit a protective effect on free radical mediated oxidative damage induced by ESWL in rabbit kidney.