Long-term evaluation of sperm parameters after coronavirus disease 2019 messenger ribonucleic acid vaccination.
Long-term evaluation of sperm parameters after coronavirus disease 2019 messenger ribonucleic acid vaccination.
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DOI：
10.1016/j.xfre.2022.07.007
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发表时间：
2022-09
期刊：
影响因子：
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通讯作者：
Ramasamy, Ranjith
中科院分区：
文献类型：
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作者：
Diaz, Parris;Dullea, Alexandra;Patel, Mehul;Blachman-Braun, Ruben;Reddy, Rohit;Khodamoradi, Kajal;Ibrahim, Emad;Bidhan, Joginder;Ramasamy, Ranjith
目的：确定新冠肺炎基因疫苗能否长期对健康年轻男性的精液参数产生负面影响。我们在达到完全接种状态前、3个月和9个月对12名男性进行了精液分析。承认有不孕症或无精子症病史的个体被排除在研究参与范围之外。在2021年9月至2022年3月期间招募了年龄在18-50岁之间的健康男性志愿者。进行精液分析并评估体积、精子密度、总活动率和总活动量(TMSC)。主要结果是基线、接种后3个月和至少9个月时TMSC的中位数变化。在我们的研究中，共有12名男性志愿者(平均年龄26[25-30]岁)。受试者在第二次接种疫苗后的中位数10个月内提供了跟踪精液样本。在接种疫苗后的基线、3个月和10个月之间，任何精液参数都没有显著变化。基线样本显示精子密度和TMSC的中位数分别为2950万/cc[9.3-49]和3100万[4-51.3]。随访9个月时，精子密度为43[20.5~63.5](P=.351)，TMSC为37.5[8.5~117.8](P=.519)。值得注意的是，在随访时，参与者的精液量和总活动率(%)没有显著变化。新冠肺炎基因疫苗和加强剂量似乎不会对接种后10个月的健康男性的精液参数产生负面影响。
To determine whether the COVID-19 mRNA vaccines can negatively impact the semen parameters of young healthy men in the long-term. We conducted semen analyses on 12 men before, 3 and 9 months after achieving fully vaccinated status. Individuals who admitted a history of infertility or previous azoospermia were excluded from study participation. Healthy male volunteers between the ages of 18-50 years old were recruited between September 2021 - March 2022. Semen analyses were performed and evaluated volume, sperm concentration, total motility, and total motile sperm count (TMSC). The primary outcome was median change in the TMSC at baseline, 3 months, and at least 9 months following vaccination. A total of 12 men volunteered in our study (median age 26 [25 - 30] years). Subjects provided follow-up semen samples at a median of 10 months following the second vaccine dose. There were no significant changes in any semen parameters between baseline, 3 months, and 10 months following vaccination. Baseline samples demonstrated median sperm concentrations and TMSC of 29.5 million/cc [9.3 – 49] and 31 million [4-51.3], respectively. At 9-month follow-up, sperm concentration and TMSC were 43 [20.5 – 63.5] (P=.351) and 37.5 [8.5 – 117.8] (P=.519), respectively. Of note, there were no significant changes in semen volume nor total motility (%) for participants at follow-up. COVID-19 mRNA vaccines and the booster dose does not appear to negatively impact the semen parameters of healthy males up to 10 months following vaccination.