MEMORY CONSOLIDATION AND THE MEDIAL TEMPORAL-LOBE - A SIMPLE NETWORK MODEL
MEMORY CONSOLIDATION AND THE MEDIAL TEMPORAL-LOBE - A SIMPLE NETWORK MODEL
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DOI：
10.1073/pnas.91.15.7041
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发表时间：
1994-07-19
影响因子：
11.1
通讯作者：
SQUIRE, LR
中科院分区：
文献类型：
--
作者：
ALVAREZ, P;SQUIRE, LR
一些形式的记忆已经被证明依赖于内侧颞叶结构系统，包括海马和相邻的皮质区（内嗅、嗅周和海马旁皮质）。然而，这一系统的作用只是暂时的，这一事实表明，在内侧颞叶受损后，最近的记忆受到损害，但非常遥远的记忆完好无损。在这里，我们回顾的证据表明，内侧颞叶记忆系统参与巩固的过程：记忆最初依赖于这个系统，但逐渐成为建立在大脑的其他区域。然后，我们回顾了一些已经提出的关于合并现象的想法，并建议对这些观点进行综合。最后，我们描述了一个简单的神经网络模型，捕捉一些关键特征的巩固。
Some forms of memory have been shown to depend on a system of medial temporal lobe structures that includes the hippocampus and the adjacent cortical areas (entorhinal, perirhinal, and parahippocampal cortex). The role of this system is only temporary, however, as indicated by the fact that, after damage to the medial temporal lobe, recent memories are impaired but very remote memories are intact. Here we review the evidence that the medial temporal lobe memory system is involved in a process of consolidation: memories are initially dependent on this system but gradually become established in other areas of the brain. We then review some of the ideas that have been proposed about the phenomenon of consolidation and suggest a synthesis of these views. Finally, we describe a simple neural network model that captures some key features of consolidation.