Polymyalgia rheumatica and giant cell arteritis: a seven-year survey.
Polymyalgia rheumatica and giant cell arteritis: a seven-year survey.
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风湿性多肌痛和巨细胞动脉炎：一项为期七年的调查。
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
A. Myles
中科院分区：
文献类型：
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作者：
A. Myles
本文报告了84例风湿性多肌痛或巨细胞动脉炎的7年随访结果。诊断被证明是不正确的七个，其中六个有多关节炎。大多数病例接受泼尼松龙治疗，对于有颅动脉炎证据的患者，每天20 mg，对于没有颅动脉炎证据的患者，每天10 mg。14名患者退出治疗（3个月至31/2年-平均21个月），但3名复发，重新开始治疗。有无动脉炎、泼尼松龙的起始剂量和随后的治疗持续时间之间无相关性。一个小组（7）接受了更高的剂量，没有明显的优势。22名患者开始每天服用5-9毫克，但13名患者由于症状控制不佳而不得不增加剂量。大多数病例存在客观的身体异常，特别是疼痛性肩关节活动受限。在治疗开始后，没有患者出现严重的疾病并发症。治疗并发症很少。7例发生脊柱骨质疏松，但未造成长期残疾。
The seven-year results of all cases (84) diagnosed as polymyalgia rheumatica or giant cell arteritis are reported. The diagnosis proved to be incorrect in seven, of which six had a polyarthritis. Most cases were treated with prednisolone, starting with 20 mg daily for those with evidence of cranial arteritis, and 10 mg for those without. Fourteen patients were withdrawn from treatment (after three months to 31/2 years--mean 21 months), but three relapsed and treatment has been restarted. There was no correlation between the presence or absence of arteritis, the starting dose of prednisolone and the subsequent duration of treatment. A small group (7) received higher doses without obvious advantage. Twenty-two started on 5-9 mg daily, but the dose had to be increased in 13 because of inadequate control of symptoms. Objective physical abnormality, particularly painful limitation of shoulder movement, was present in most cases. No patient developed a serious complication of the disease after treatment had been started. Complications of treatment were infrequent. Spinal osteoporosis occurred in seven, but did not cause long-term disability.