Do All Coccidia Follow the Same Trafficking Rules?
Do All Coccidia Follow the Same Trafficking Rules?
复制标题
DOI：
10.3390/life11090909
复制
发表时间：
2021-08-31
期刊：
影响因子：
--
通讯作者：
Tomley FM
中科院分区：
文献类型：
--
作者：
Marugan-Hernandez V;Sanchez-Arsuaga G;Vaughan S;Burrell A;Tomley FM
球虫是顶复门的一个亚类，包括几个属的原生动物寄生虫，导致人类和动物的重要疾病，弓形虫成为研究球虫分子和细胞过程的“模式生物”。对T.弓形虫速殖子和广泛可用的分子工具揭示了许多与其细胞运输和寄生虫分泌细胞器的作用有关的机制，这些机制在寄生虫-宿主相互作用中至关重要。然而，T.在描述弓形虫速殖子对其他球虫寄生虫的作用机制时应谨慎。在这篇综述中，我们考虑了艾美耳球虫寄生虫的已发表数据，艾美耳球虫是一种球虫属，包括数千种，其感染对家畜和家禽有重要影响。这些研究表明，球虫具有共同的和多样化的蛋白质运输和分泌机制，可能与它们的生命周期有关。而贩运和分泌似乎是很好的转化之前和宿主细胞入侵期间，出现重要的差异，一旦内源性发展开始。因此，进一步的研究来验证T.弓形虫速殖子应在更广泛的球虫中进行（包括弓形虫速殖子）。弓形虫子孢子）。此外，还需要对重要致病球虫进行进一步的属特异性研究，以揭示与其特定生命周期和宿主相关的发病机制的个体分子机制。
The Coccidia are a subclass of the Apicomplexa and include several genera of protozoan parasites that cause important diseases in humans and animals, with Toxoplasma gondii becoming the ‘model organism’ for research into the coccidian molecular and cellular processes. The amenability to the cultivation of T. gondii tachyzoites and the wide availability of molecular tools for this parasite have revealed many mechanisms related to their cellular trafficking and roles of parasite secretory organelles, which are critical in parasite-host interaction. Nevertheless, the extrapolation of the T. gondii mechanisms described in tachyzoites to other coccidian parasites should be done carefully. In this review, we considered published data from Eimeria parasites, a coccidian genus comprising thousands of species whose infections have important consequences in livestock and poultry. These studies suggest that the Coccidia possess both shared and diversified mechanisms of protein trafficking and secretion potentially linked to their lifecycles. Whereas trafficking and secretion appear to be well conversed prior to and during host-cell invasion, important differences emerge once endogenous development commences. Therefore, further studies to validate the mechanisms described in T. gondii tachyzoites should be performed across a broader range of coccidians (including T. gondii sporozoites). In addition, further genus-specific research regarding important disease-causing Coccidia is needed to unveil the individual molecular mechanisms of pathogenesis related to their specific lifecycles and hosts.
登录
查看更多内容
影响因子：
3.1
作者：
BOHNE, W;HEESEMANN, J;GROSS, U
通讯作者：
GROSS, U
影响因子：
4.8
作者：
Chaturvedi, S;Qi, HL;Joiner, KA
通讯作者：
Joiner, KA
影响因子：
4
作者：
de Venevelles, Patrick;Chich, Jean Francois;Labbe, Marie
通讯作者：
Labbe, Marie
影响因子：
6.7
作者：
Carmeille R;Schiano Lomoriello P;Devarakonda PM;Kellermeier JA;Heaslip AT
通讯作者：
Heaslip AT
影响因子：
28.3
作者：
Aquilini E;Cova MM;Mageswaran SK;Dos Santos Pacheco N;Sparvoli D;Penarete-Vargas DM;Najm R;Graindorge A;Suarez C;Maynadier M;Berry-Sterkers L;Urbach S;Fahy PR;Guérin AN;Striepen B;Dubremetz JF;Chang YW;Turkewitz AP;Lebrun M
通讯作者：
Lebrun M