Neural circuits for coping with social defeat
Neural circuits for coping with social defeat
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DOI：
10.1016/j.conb.2019.11.016
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发表时间：
2020-02-01
影响因子：
5.7
通讯作者：
Lin, Dayu
中科院分区：
文献类型：
--
作者：
Diaz, Veronica;Lin, Dayu
当食物、领地和潜在配偶等资源有限时，同一物种的动物之间的竞争是不可避免的。经过一轮轮的竞争互动，赢家和输家就已确定。失去是一种痛苦的经历，无论是身体上还是心理上。失败者不仅需要部署一套特定于物种的防御行为，以最大程度地减少失败期间的身体伤害，而且还需要针对胜利者调整自己的行为，以避免在未来的战斗中他们可能处于不利地位。防御行为的表达以及伴随失败而来的快速而持久的行为变化必须得到复杂的神经回路的支持。这篇综述总结了与应对社交失败有关的大脑区域，一个以基底外侧杏仁核为中心，另一个以腹内侧下丘脑为中心。还讨论了我们的知识差距和可能有助于指导未来实验的假设。
When resources, such as food, territory, and potential mates are limited, competition among animals of the same species is inevitable. Over bouts of agonistic interactions, winners and losers are determined. Losing is a traumatic experience, both physically and psychologically. Losers not only need to deploy a set of species-specific defensive behaviors to minimize the physical damage during defeat, but also adjust their behavior towards the winners to avoid future fights in which they are likely disadvantaged. The expression of defensive behaviors and the fast and long-lasting changes in behaviors accompanying defeat must be supported by a complex neural circuit. This review summarizes the brain regions that have been implicated in coping with social defeat, one centered on basolateral amygdala and the other on ventromedial hypothalamus. Gaps in our knowledge and hypotheses that may help guide future experiments are also discussed.