How do prescription opioid users differ from users of heroin or other drugs in psychopathology: results from the National Epidemiologic Survey on Alcohol and Related Conditions.
How do prescription opioid users differ from users of heroin or other drugs in psychopathology: results from the National Epidemiologic Survey on Alcohol and Related Conditions.
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DOI：
10.1097/adm.0b013e3181e0364e
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发表时间：
2011-03
影响因子：
5.5
通讯作者：
Blazer DG
中科院分区：
文献类型：
--
作者：
Wu LT;Woody GE;Yang C;Blazer DG
在全国成人样本中研究处方阿片类药物使用者、海洛因使用者和非阿片类药物使用者的物质使用和精神疾病。2001-2002年全国酒精及相关疾病流行病学调查数据分析（N= 43，093）。在9140名非法或非处方药物使用者中确定了四组：海洛因-其他阿片类药物使用者（1.0%;使用海洛因和其他阿片类药物），其他阿片类药物仅使用者（19.8%;使用其他阿片类药物但从未使用海洛因），海洛因仅使用者（0.5%;使用海洛因但从未使用其他阿片类药物）和非阿片类药物使用者（78.7%;使用药物但从未使用海洛因或其他阿片类药物）。在调整了社会经济特征、药物滥用治疗史和家族性药物滥用的变化后，与其他组相比，海洛因-其他阿片类药物使用者发生几种药物使用障碍（可卡因、致幻剂、镇静剂、苯丙胺和镇静剂）的几率更大;与其他阿片类药物使用者相比，单纯海洛因使用者发生镇静剂和镇静剂使用障碍的几率降低。非阿片类药物使用者与其他仅使用阿片类药物的使用者相比，所有物质使用障碍和其他精神障碍（情绪，焦虑，病理性赌博和人格）的几率降低。去年其他仅使用类阿片的吸毒者也报告生活质量得分略低于去年非类阿片吸毒者。所有类阿片使用组的物质使用障碍发生率均高于非类阿片吸毒者，这些发生率在海洛因-其他类阿片使用者中尤其高。研究结果表明，在研究和治疗中需要区分这四个群体，因为他们可能有不同的自然病史和治疗需求。
To study substance use and psychiatric disorders among prescription opioid users, heroin users, and non-opioid drug users in a national sample of adults. Analyses of data from the 2001–2002 National Epidemiologic Survey on Alcohol and Related Conditions (N=43,093). Four groups were identified among 9140 illicit or non-prescribed drug users: heroin-other opioid users (1.0%; used heroin and other opioids), other opioid-only users (19.8%; used other opioids but never heroin), heroin-only users (0.5%; used heroin but never other opioids), and non-opioid drug users (78.7%; used drugs but never heroin or other opioids). After adjusting for variations in socioeconomic characteristics, history of substance abuse treatment, and familial substance abuse, heroin-other opioid users had greater odds of several substance use disorders (cocaine, hallucinogen, sedative, amphetamine, and tranquilizer) as compared with the other groups; heroin-only users had reduced odds of sedative and tranquilizer use disorders as compared with other opioid-only users. Non-opioid drug users had reduced odds of all substance use disorders and other mental disorders (mood, anxiety, pathological gambling, and personality) as compared with other opioid-only users. Past-year other opioid-only users also reported slightly lower scores on quality of life than past-year non-opioid drug users. All opioid use groups had higher rates of substance use disorders than non-opioid drug users, and these rates were particularly elevated among heroin-other opioid users. Findings suggest the need to distinguish between these four groups in research and treatment as they may have different natural histories and treatment needs.