Establishing cognitive baseline in three generations: Framingham Heart Study.
Establishing cognitive baseline in three generations: Framingham Heart Study.
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DOI：
10.1002/dad2.12416
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发表时间：
2023-01
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代际变化需要重新校准规范的认知测量，以检测每一代人中表明痴呆风险的变化。我们进行了线性回归，以比较弗雷明汉心脏研究（FHS，n = 4787）中三代队列中基线的八项神经心理学（NP）测试，并进行了 Cox 回归以调查 NP 测试与特定代痴呆风险的关系。 FHS 第二代和第三代在 7 项 NP 测试中的表现优于第一代（0.14-0.81 标准差改进，P ≤ .001），而第二代和第三代在 8 项 NP 测试中的 6 项中表现相似（P > .05）。在相似性测试中，一个标准差的更好表现与第二代痴呆症风险的降低更高相关（35% vs. 24%，P 交互 = .02）。我们的研究结果表明，诊断认知障碍和痴呆症的认知评估需要基于队列的规范。
Generational changes warrant recalibrating normative cognitive measures to detect changes indicative of dementia risk within each generation. We performed linear regressions to compare eight neuropsychological (NP) tests among three‐generation cohorts at baseline in Framingham Heart Study (FHS, n = 4787) and conducted Cox regressions to investigate the relationships of NP tests with generation‐specific dementia risk. The FHS second and third generations performed better than the first generation for seven NP tests (0.14–0.81 standard deviation improvement, P ≤ .001) while the second and third generations performed similarly for six of eight NP tests (P > .05). One standard deviation better performance was associated with a higher reduction in incident dementia risk in the second than the first generation (35% vs. 24%, P interaction = .02) for the similarities test. Our findings suggest cohort‐based norms are needed for cognitive assessment for the diagnosis of cognitive impairment and dementia.