Moderate-to-high-intensity training and a hypocaloric Mediterranean diet enhance endothelial progenitor cells and fitness in subjects with the metabolic syndrome
Moderate-to-high-intensity training and a hypocaloric Mediterranean diet enhance endothelial progenitor cells and fitness in subjects with the metabolic syndrome
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DOI：
10.1042/cs20110477
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发表时间：
2012-09-01
期刊：
影响因子：
6
通讯作者：
Fuentes-Jimenez, Francisco
中科院分区：
文献类型：
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作者：
Marcelo Fernandez, Juan;Rosado-Alvarerz, Daniel;Fuentes-Jimenez, Francisco
内皮祖细胞（endothelial progenitor cell， EPC）数量的减少可以解释代谢综合征中动脉粥样硬化的发生和进展。尽管近年来许多研究都集中在地中海饮食模式和MetS上，但这种饮食搭配/不搭配中高强度耐力训练对EPCs水平和CrF（心肺功能）的影响尚不清楚。在本研究中，目的是评估地中海饮食低热量模型加或不加中高强度耐力训练对met患者EPC数和CrF的影响。因此，45例met患者（50-66岁）被随机分为低热量MeD（地中海饮食）或MeDE （MeD加中至高强度耐力训练）12周干预组。训练包括每周两次有监督的训练[80% MaxHR（最大心率）；腿部和手臂蹬车]和一次在家锻炼（65-75% MaxHR；步行由心率监测器控制）。在研究结束时，测定了以下方面的变化：(i) EPC数[CD34(+) KDR+（激酶插入结构域受体）],(ii) CrF变量和（iii） MetS成分和IRH（缺血反应性充血）。总共有40名受试者完成了12周的研究，每组20人。与MeD干预相比，MeDE导致EPC数和CrF的增加更大(P
A reduction in EPC (endothelial progenitor cell) number could explain the development and progression of atherosclerosis in the MetS (metabolic syndrome). Although much research in recent years has focused on the Mediterranean dietary pattern and the MetS, the effect of this diet with/without moderate-to-high-intensity endurance training on EPCs levels and CrF (cardiorespiratory fitness) remains unclear. In the present study, the objective was to assess the effect of a Mediterranean diet hypocaloric model with and without moderate-to-high-intensity endurance training on EPC number and CrF of MetS patients. Thus 45 MetS patients (50-66 years) were randomized to a 12-week intervention with the hypocaloric MeD (Mediterranean diet) or the MeDE (MeD plus moderate-to-high-intensity endurance training). Training included two weekly supervised sessions [80% MaxHR (maximum heart rate); leg and arm pedalling] and one at-home session (65-75% MaxHR; walking controlled by heart rate monitors). Changes in: (i) EPC number [CD34(+) KDR+ (kinase insert domain-containing receptor)], (ii) CrF variables and (iii) MetS components and IRH (ischaemic reactive hyperaemia) were determined at the end of the study. A total of 40 subjects completed all 12 weeks of the study, with 20 in each group. The MeDE led to a greater increase in EPC numbers and CrF than did the MeD intervention (P