Antiepileptic drug use in nursing home residents: Effect of age, gender, and comedication on patterns of use

Antiepileptic drug use in nursing home residents: Effect of age, gender, and comedication on patterns of use
复制标题

DOI：
10.1111/j.1528-1157.1998.tb01294.x
复制
发表时间：
1998-10-01
期刊：
EPILEPSIA
影响因子：
5.6
通讯作者：
Leppik, IE
Leppik, IE
中科院分区：
医学1区
文献类型：
--
作者：
Lackner, TE;Cloyd, JC;Leppik, IE

文献摘要

被引文献

相似文献

目的：根据年龄、性别和可与抗癫痫药相互作用的通信的使用情况，检查疗养院抗癫痫药物的使用情况。方法：从全美疗养院居民的计算机医疗记录(集1，43,757；集2，41,386)中对抗癫痫药的使用进行两点流行率评估。结果：10.5%的居民收到了抗癫痫药。在65-84岁的年龄组中，15%的人接受了抗精神病药治疗，而在85岁以上的人中，这一比例为6.1%(p&lt；0.001)。存在性别差异：13.4%的男性居民和9.4%的女性居民接受了抗癫痫药物治疗(p&lt；0.001)。最常用的抗癫痫药物是苯妥英、卡马西平、氯硝西潘或苯巴比妥。AED受助者的平均常规用药次数为5.6次，高于其他居民的平均4.6次。结论：老年养老院居民普遍使用AEDs。男性和65-85岁的人比女性或85岁以上的人更有可能接受抗癫痫药物治疗。与其他居民相比，AED患者接受的常规药物更多，包括改变肝脏新陈代谢和临床反应的联合药物。年龄和性别差异的原因尚不清楚，需要进一步研究。
Purpose: Examine antiepileptic drug (AED) use in nursing homes by age, gender, and use of comedication that can interact with AEDs.Methods: Two point-prevalence evaluations of AED use from computerized medical records of nursing home residents throughout the United States (set 1, 43,757; set 2, 41,386) 65 years and older serviced by PHARMERICA.Results: 10.5% of residents received an AED. Of the age group 65-84 years, 15% received an AED compared with 6.1% of those 85 years or older (p < 0.001). Gender differences were present: 13.4% of the male residents and 9.4% of the female residents were treated with an AED (p < 0.001). The most frequently prescribed AEDs were phenytoin, carbamazepine, clonazepam, or phenobarbital. The average number of routine medications taken by AED recipients was 5.6, greater than the average of 4.6 for other residents.Conclusions: AEDs are extensively prescribed for elderly nursing home residents. Men and persons aged 65-85 years were more likely to receive AEDs than were women or those older than 85 years. AED recipients receive more routine medications than do other residents, including co-medications that alter hepatic metabolism and clinical response. The reasons for age and gender differences are unclear and require further study.