A case of primary thyroid squamous cell cancer : transformation from benign tumour associated with chronic thyroiditis?
A case of primary thyroid squamous cell cancer : transformation from benign tumour associated with chronic thyroiditis?
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原发性甲状腺鳞状细胞癌一例：慢性甲状腺炎相关良性肿瘤转化？
DOI：
10.1136/bcr.10.2008.1137
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发表时间：
2009
期刊：
影响因子：
0.9
通讯作者：
E
中科院分区：
文献类型：
--
作者：
Kondo;T.;Matsuyoshi;A.;Matsuyoshi;H.;Goto;R.;Ono;K.;Honda;Y.;Iyama;K.;Tsu ruzoe;K.;Miyamura;N. and Araki;E
原发性甲状腺鳞状细胞癌（SCT）是一种罕见的恶性肿瘤，死亡率高。本报告描述了一名女性患者，她患有原发性SCT。癌症被确定为急性疼痛肿胀的甲状腺，当病人定期观察她的慢性甲状腺炎在我们的门诊诊所。尽管组织学检查（包括p53和MIB-1指数分析）表明癌症具有高度恶性潜力，但迄今为止，该患者已通过手术和放射治疗成功治疗，存活超过34个月，没有复发或转移的迹象。早期诊断和及时治疗可能是成功治疗该患者的关键。进一步的观察和研究是必要的，以澄清长期生存的机制，并找到一个更好的治疗疾病。
Primary squamous cell cancer of the thyroid gland (SCT) is a rare malignant tumour and is associated with a high mortality. A female patient who suffered from primary SCT is described in this report. The cancer was identified with acute painful swelling of the thyroid gland, when the patient was under periodical observation for her chronic thyroiditis at our outpatient’s clinic. In spite of the highly malignant potential of the cancer as indicated by histological examinations, including p53 and MIB-1 index analyses, the patient has been successfully treated so far with surgery and radiation therapy, surviving for more than 34 months with no sign of recurrence or metastasis. Early diagnosis and prompt treatment might have been essential for the successful management of this patient. Further observations and investigations are necessary to clarify the mechanisms of the long survival and to find a better treatment for the disease.