The role of the hippocampus in memory for the temporal order of a sequence of odors
The role of the hippocampus in memory for the temporal order of a sequence of odors
复制标题
DOI：
10.1037//0735-7044.116.2.286
复制
发表时间：
2002-04-01
影响因子：
1.9
通讯作者：
Barua, LA
中科院分区：
文献类型：
--
作者：
Kesner, RP;Gilbert, PE;Barua, LA
研究人员评估了大鼠对一系列气味的时间顺序的记忆。在挖掘杯中向每只老鼠呈现混合在沙子中的 5 种气味序列，每次一种，每次试验的顺序各不相同。每个杯子里都埋着一份奖励。第5种气味后，前5种气味中的2种同时呈现；为了获得奖励，老鼠必须选择序列中最早出现的气味。 1、2 或 3 的时间间隔代表序列中 2 种气味之间出现的气味数量。一旦达到术前标准，每只大鼠都会接受海马（HIP）或皮质控制病变，并重新测试任务。在术后试验中，HIP 组相对于对照组受损。然而，HIP 小组可以区分这些气味。数据表明，海马体参与及时分离感觉事件，以便将一个事件与另一个事件分开记住。
Memory for the temporal order of a sequence of odors was assessed in rats. A sequence of 5 odors mixed in sand was presented in digging cups, 1 at a time, to each rat in a sequence that varied on each trial. A reward was buried in each cup. After the 5th odor, 2 of the previous 5 odors were presented simultaneously; to receive a reward, the rat had to choose the odor that occurred earliest in the sequence. Temporal separations of 1, 2, or 3 represented the number of odors that occurred between the 2 odors in the sequence. Once a preoperative criterion was reached, each rat received a hippocampal (HIP) or cortical control lesion and was retested on the task. On postoperative trials, the HIP group was impaired relative to controls. However, the HIP group could discriminate between the odors. The data suggest that the hippocampus is involved in separating sensory events in time so that 1 event can be remembered separately from another event.