Principles for designing randomized preventive trials in mental health: An emerging developmental epidemiology paradigm
Principles for designing randomized preventive trials in mental health: An emerging developmental epidemiology paradigm
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DOI：
10.1023/a:1022142021441
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发表时间：
1999-10-01
影响因子：
3.1
通讯作者：
Liao, J
中科院分区：
文献类型：
--
作者：
Brown, CH;Liao, J
现在正在使用一种新的基于人口的范例来指导用于测试发育模型的预防性试验的设计。我们讨论了几个正在进行的随机预防性试验的设计要素，这些试验涉及降低离婚儿童、表现出行为或学习问题的儿童以及父母正在接受抑郁症治疗的儿童的风险。为了利用这一范式休息发展模型，我们引入了三类设计问题：为前随机化设计、为干预设计和为干预后设计。对于这些领域中的每一个领域，我们都提供了功率计算的定量结果。从干预前措施、干预单位、分配、平衡、前测和后测措施的数量以及调节效果的检验的受试者之间的差异来讨论这些能量计算的科学意义和成本意义。
An emerging population-based paradigm is now being used to guide the design of preventive trials used to test developmental models. We discuss elements of the designs of several ongoing randomized preventive trials involving reduction of risk for children of divorce, for children who exhibit behavioral or learning problems, and for children whose parents are being treated for depression. To rest developmental models using this paradigm, we introduce three classes of design issues: design for prerandomization, design for intervention and design for postintervention. For each of these arena, we present quantitative results from power calculations. Both scientific and cost implications of these power calculations are discussed in terms of variation among subjects on preintervention measures, unit of intervention, assignment, balancing, number of pretest and posttest measures, and the examination of moderation effects.