MANAGEMENT OF CARCINOID TUMORS
MANAGEMENT OF CARCINOID TUMORS
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DOI：
10.1002/1097-0142(197009)26:3
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发表时间：
1970-01-01
期刊：
影响因子：
6.2
通讯作者：
MARTIN, RG
中科院分区：
文献类型：
--
作者：
MARTIN, RG
在德克萨斯大学M。D.休斯顿安德森医院和肿瘤研究所介绍。在组织学上，类癌不能区分为良性或恶性。它们生长缓慢，手术切除是首选治疗方法。小病灶（2 cm以下）的局部切除和较大病灶的沿着区域淋巴结的根治性切除是适用的。在我们的研究中，25%的病变发生在患有其他原发性癌症的患者中。它们可以是多个，通常是回肠病变的情况。一定数量的患者发展为类癌综合征，具有其全部或许多特征性症状。化疗和X射线治疗在这些患者的管理中使用有限。抗5-羟色胺药物和可的松可能对类癌综合征的治疗有益。在我们的研究中，所有患有该综合征的患者均死亡;但3名患者死于该疾病而没有出现该综合征。所有其他死亡均归因于与类癌病变无关的原因，通常来自共存的恶性肿瘤。
A series of 59 carcinoid tumors observed at the University of Texas M. D. Anderson Hospital and Tumor Institute at Houston is presented. Histologically, carcinoid tumors cannot be differentiated as being benign or malignant. They are slow growing, and surgical excision is the preferred treatment. Local excision for small (under 2 cm) lesions and more radical excisions along with the regional lymph nodes for larger lesions are indicated. Twenty‐five percent of the lesions in our study developed in patients having other primary cancers. They may be multiple, as often is the case in ileal lesions. A certain number of patients develop the carcinoid syndrome with all or many of its characteristic symptoms. Chemotherapy and x‐ray therapy have limited use in the management of these patients. Antiserotonin drugs and cortisone may be beneficial in the therapy of carcinoid syndrome. In our study, all patients with the syndrome died; but 3 patients died from the disease without having the syndrome. All other deaths were attributed to causes not related to the carcinoid lesions, often from coexisting malignancies.