Transmission of hepatitis E virus from rabbits to cynomolgus macaques.
Transmission of hepatitis E virus from rabbits to cynomolgus macaques.
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戊型肝炎病毒从兔子到食蟹猴的传播
DOI：
10.3201/eid1904.120827
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发表时间：
2013-04
影响因子：
11.8
通讯作者：
Zhuang H
中科院分区：
文献类型：
--
作者：
Liu P;Bu QN;Wang L;Han J;Du RJ;Lei YX;Ouyang YQ;Li J;Zhu YH;Lu FM;Zhuang H
最近在中华人民共和国和美国的兔子中发现戊型肝炎病毒（HEV）株，揭示了兔子是另一个值得注意的HEV储存库。然而，来自兔子的HEV是否能感染人类尚不清楚。为了研究兔戊型肝炎病毒（HEV）的人畜共患潜力和致病机制，我们用中国兔HEV株感染2只食蟹猴和2只家兔。两只猴均发生典型肝炎;它们表现出肝酶升高、病毒血症、粪便标本中的病毒脱落和血清转化。将猕猴体内传递的HEV的全基因组序列与接种物的全基因组序列进行比较，核苷酸同源性为99.8%。兔戊型肝炎病毒RNA（正链和负链）可检测到各种组织从实验感染的兔子，表明肝外复制可能是常见的。因此，戊型肝炎病毒可以从家兔传播给食蟹猴，提示家兔可能是人戊型肝炎病毒的一个新的感染源。
The recent discovery of hepatitis E virus (HEV) strains in rabbits in the People’s Republic of China and the United States revealed that rabbits are another noteworthy reservoir of HEV. However, whether HEV from rabbits can infect humans is unclear. To study the zoonotic potential for and pathogenesis of rabbit HEV, we infected 2 cynomolgus macaques and 2 rabbits with an HEV strain from rabbits in China. Typical hepatitis developed in both monkeys; they exhibited elevated liver enzymes, viremia, virus shedding in fecal specimens, and seroconversion. Comparison of the complete genome sequence of HEV passed in the macaques with that of the inoculum showed 99.8% nucleotide identity. Rabbit HEV RNA (positive- and negative-stranded) was detectable in various tissues from the experimentally infected rabbits, indicating that extrahepatic replication may be common. Thus, HEV is transmissible from rabbits to cynomolgus macaques, which suggests that rabbits may be a new source of human HEV infection.