Interleukin-6: an emerging regulator of pathological pain.
Interleukin-6: an emerging regulator of pathological pain.
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Interleukin-6：一种新兴的病理性疼痛调节剂
DOI：
10.1186/s12974-016-0607-6
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发表时间：
2016-06-07
影响因子：
9.3
通讯作者：
Tian YK
中科院分区：
文献类型：
--
作者：
Zhou YQ;Liu Z;Liu ZH;Chen SP;Li M;Shahveranov A;Ye DW;Tian YK
白细胞介素-6是一种具有广泛生物学效应的炎性细胞因子。神经炎症在病理性疼痛的发生发展中起着重要的作用。近年来，各种病理性疼痛模型显示，脊髓和背根神经节中白细胞介素-6及其受体的表达水平升高。此外，白细胞介素-6的管理可能会导致机械异常性疼痛和热痛觉过敏，和鞘内注射抗白细胞介素-6中和抗体减轻这些疼痛相关的行为。这些研究表明白细胞介素-6在病理性疼痛中起关键作用。本文就白细胞介素6在骨癌、周围神经损伤、脊髓损伤、化疗性周围神经病变、完全弗氏佐剂注射和角叉菜胶注射等病理性疼痛中的作用和机制作一综述。了解和调节白细胞介素-6可能是一个有趣的导致病理性疼痛的新的治疗策略。
Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been widely demonstrated that neuroinflammation plays a critical role in the development of pathological pain. Recently, various pathological pain models have shown elevated expression levels of interleukin-6 and its receptor in the spinal cord and dorsal root ganglia. Additionally, the administration of interleukin-6 could cause mechanical allodynia and thermal hyperalgesia, and an intrathecal injection of anti-interleukin-6 neutralizing antibody alleviated these pain-related behaviors. These studies indicated a pivotal role of interleukin-6 in pathological pain. In this review, we summarize the recent progress in understanding the roles and mechanisms of interleukin-6 in mediating pathological pain associated with bone cancer, peripheral nerve injury, spinal cord injury, chemotherapy-induced peripheral neuropathy, complete Freund’s adjuvant injection, and carrageenan injection. Understanding and regulating interleukin-6 could be an interesting lead to novel therapeutic strategies for pathological pain.