Advances in the integration of metabolomics and metagenomics for human gut microbiome and their clinical applications
Advances in the integration of metabolomics and metagenomics for human gut microbiome and their clinical applications
复制标题
DOI：
10.1016/j.trac.2023.117248
复制
发表时间：
2023-08
期刊：
影响因子：
--
通讯作者：
F. Puig-Castellví;R. Pacheco‐Tapia;Maxime Deslande;Manyi Jia;P. Andrikopoulos;K. Chechi;A. Bonnefond;P. Froguel;M. Dumas
中科院分区：
文献类型：
--
作者：
F. Puig-Castellví;R. Pacheco‐Tapia;Maxime Deslande;Manyi Jia;P. Andrikopoulos;K. Chechi;A. Bonnefond;P. Froguel;M. Dumas
人类微生物组及其代谢输出在塑造人类健康和疾病方面发挥着重要作用。宿主-微生物串扰通常使用代谢组学和宏基因组学来表征，但大部分微生物代谢物和肠道微生物的分子功能仍然未知。本综述总结了单独使用代谢组学或与宏基因组相结合注释和发现人类肠道微生物组新代谢物的策略，并提出了结合这两种类型的数据以获得生物学见解的数据分析方法。还讨论了肠道微生物组研究在生物标志物筛选、精准医学、微生物组医学和药物发现中的应用，以及该研究领域的观点、挑战和局限性。
The human microbiome and its metabolic output play an important role in shaping human health and disease. The host-microbe crosstalk is often characterised using metabolomics and metagenomics, yet a large proportion of microbial metabolites and the molecular functions of gut microbes remain unknown. This review summarises the strategies for annotation and discovery of the novel metabolites from the human gut microbiome, either using metabolomics alone or in combination with metagenomics, and presents data analysis methods for combining these two types of data to obtain biological insights. Applications of the gut microbiome research in biomarker screening, precision medicine, microbiome medicine, and drug discovery are also discussed, along with the perspectives, challenges and limitations of this research field.