Heating Induced by Therapeutic Ultrasound in the Presence of Magnetic Nanoparticles
Heating Induced by Therapeutic Ultrasound in the Presence of Magnetic Nanoparticles
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DOI：
10.1021/acsami.8b02496
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发表时间：
2018-04-11
影响因子：
9.5
通讯作者：
Jozefczak, Arkadiusz
中科院分区：
文献类型：
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作者：
Kaczmarek, Katarzyna;Hornowski, Tomasz;Jozefczak, Arkadiusz
超声热疗用于抗癌治疗（如放射治疗或化学治疗）的效率可以通过使用声敏剂来提高，声敏剂是增强声能的衰减和耗散的材料。我们建议使用磁性纳米粒子作为声敏剂，因为它们的生物相容性，无毒，并在几个医疗应用中的常见用途。合成磁性材料，然后将其以磁流体的形式掺入琼脂仿组织模型中。超声热疗研究在不同的超声频率和磁性纳米颗粒的浓度下进行。基于传热方程的理论模型和实验结果显示出良好的一致性，并证实，在超声加热过程中的温度上升，在组织模仿phantomy掺杂声敏剂是大于在一个纯琼脂幻影。此外，Pennes的生物热方程的基础上，它考虑了血液灌注和代谢热，热剂量和损伤形状后，超声处理的假设组织确定。
The efficiency of ultrasound hyperthermia for anti-cancer treatments such as radiotherapy or chemotherapy can be improved by using sonosensitizers, which are materials that enhance the attenuation and dissipation of acoustic energy. We propose the use of magnetic nanoparticles as sonosensitizers because of their biocompatibility, nontoxicity, and common use in several medical applications. A magnetic material was synthetized and then incorporated in the form of a magnetic fluid in agar tissue-mimicking phantoms. Ultrasound hyperthermia studies were conducted at various ultrasound frequencies and concentrations of magnetic nanoparticles in the phantoms. The theoretical modeling based on a heat transfer equation and the experimental results show good agreement and confirm that the temperature rise during ultrasound heating in tissue mimicking phantoms doped with sonosensitizers is greater than that in a pure agar phantom. Furthermore, on the basis of Pennes' bio-heat equation, which takes into consideration the blood perfusion and metabolic heat, the thermal dose and lesion shapes after sonication were determined for a hypothetical tissue.